Phytochemical Composition for Brown Adipocyte Recruitment
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Solution Overview
Problem
Current compositions and therapies fail to effectively maintain energy homeostasis and promote the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT) for enhanced energy expenditure, which is crucial in managing obesity and related metabolic disorders.
Innovation Solution
A composition comprising Cyperus rotundus extract and Passiflora edulis extract standardized to contain Piceatannol, Scirpusin B, Scirpusin A, and Cyperusphenols, which are brought into contact with mammalian adipocytes to induce the recruitment of brown or beige adipocytes, enhance mitochondrial thermogenesis, and inhibit adipogenesis, thereby increasing energy expenditure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional compositions and therapies are used, then treatment of obesity and metabolic disorders is attempted, but energy homeostasis is not effectively maintained and WAT to BAT conversion is not promoted
Solution Approach 1:
The patent changes the chemical composition parameters by standardizing the extract to contain specific concentrations of stilbenes (6-10% w/w), piceatannol (0.5-2% w/w), and other compounds. This parameter optimization enables effective WAT to BAT conversion and maintains energy homeostasis, resolving the contradiction between reliable homeostasis maintenance and productive energy expenditure enhancement
Solution Approach 2:
The patent creates a composite phytochemical composition combining multiple extracts (Cyperus rotundus and Passiflora edulis) with complementary active compounds. This composite approach synergistically promotes brown adipocyte recruitment, mitochondrial thermogenesis, and energy expenditure while maintaining energy homeostasis, overcoming the limitations of single-compound therapies
2Productivity
If WAT to BAT conversion is promoted through plant-based compounds, then energy expenditure increases, but effective maintenance of energy homeostasis remains unaddressed
Solution Approach 1:
The standardized composition performs multiple functions simultaneously: it recruits brown adipocytes, enhances mitochondrial thermogenesis, increases energy expenditure, and maintains energy homeostasis. This multi-functionality resolves the contradiction by achieving both high productivity in energy expenditure and reliability in homeostasis maintenance through a single integrated therapeutic approach
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively induces the expression of genes and proteins that promote brown fat conversion, leading to increased mitochondrial thermogenesis and reduced adipogenesis, resulting in enhanced energy expenditure and weight management in mammals.
Implementation Method 1
induce enhanced expression of mitochondrial uncoupling protein-1 to result in increased mitochondrial thermogenesis in differentiated brown adipocytes and beige or brite adipocytes
Data Source
AI summary
The invention discloses a composition comprising Cyperus rotundus extract and Passiflora edulis extract comprising piceatannol, scirpusin B, scirpusin A, cyperusphenol A and cyperusphenol B, standardized to contain 6-10% w/w total stilbenes and a process of preparing the composition thereof. The invention also discloses the use of the above mentioned composition in enhancing energy expenditure in mammalian adipose cellular systems by the conversion of white adipose tissues to brown adipose tissues, inhibition of adipogenesis and for preventing weight gain in mammals.