Phytochemical Oil Extraction via Enzymatic Hydrolysis and Phase Transitions

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Solution Overview

Problem

Current methods for extracting cannabinoids, curcuminoids, and ginsenosides from plant sources are inefficient, costly, and lack chemical stability, toxicity, and organic sustainability.

Innovation Solution

A method involving freezing plant parts, reducing them to powder, suspending in an aqueous buffer with pectinase and cellulase, steam drying, and extracting phytochemical oil using ethanol and supercritical CO2, followed by chromatographic purification.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If conventional extraction methods are used for cannabinoids, curcuminoids, and ginsenosides, then extraction can be performed with simple equipment, but the extraction efficiency is low and the process is costly

Engineering Contradiction:
Improveextraction efficiencyVSAvoidextraction process complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The plant material is frozen before extraction, which preliminary prepares the cellular structure for more efficient compound release during the extraction process, thereby improving extraction efficiency without requiring complex equipment

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The extraction process utilizes phase transitions by changing temperature parameters (freezing followed by controlled heating during extraction) to enhance the release and extraction of phytochemicals, improving efficiency while maintaining a relatively simple process framework

Inventive Principle:
Principle #35Parameter changes

2Stability of the object's composition

If conventional extraction solvents are used, then the extraction process is simple, but the extracted phytochemicals lack chemical stability and may be toxic

Engineering Contradiction:
Improvechemical stability of phytochemicalsVSAvoidextraction process complexity
Core Design Contradiction:
Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The extraction process uses controlled temperature parameters and phase transitions (freezing, controlled heating, evaporation) to preserve the chemical stability of phytochemicals while maintaining a relatively simple extraction setup without requiring complex stabilization equipment

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The process replaces harsh chemical solvents with a controlled physical extraction system using phase transitions and enzymatic action, eliminating toxicity concerns while maintaining chemical stability through physical rather than chemical means

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Stability of the object's composition

If conventional drying methods are used, then the process is simple and quick, but the phytochemicals lose chemical stability and bioactivity

Engineering Contradiction:
Improvechemical stability of phytochemicalsVSAvoiddrying time
Core Design Contradiction:
Stability of the object's compositionVSLoss of time

Solution Approach 1:

The process utilizes controlled phase transitions including freezing and controlled evaporation to remove water while preserving phytochemical stability, achieving both stability and reasonable processing time without requiring complex drying equipment

Inventive Principle:
Principle #36Phase transitions

Solution Approach 2:

The plant material is frozen before extraction and drying, which preliminary prepares the structure for more efficient water removal while protecting phytochemicals from degradation during the drying process, reducing both time and stability loss

Inventive Principle:
Principle #10Preliminary action

4Productivity

If non-organic extraction methods are used, then the extraction efficiency is high, but the process is toxic and not environmentally sustainable

Engineering Contradiction:
Improveextraction efficiencyVSAvoidtoxicity and environmental harm
Core Design Contradiction:
ProductivityVSObject-generated harmful factors

Solution Approach 1:

The process replaces toxic chemical solvents with a physical extraction system based on phase transitions, freezing, and controlled evaporation, achieving high extraction efficiency while eliminating toxicity and environmental harm

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The freezing and phase transition process allows the plant material itself to facilitate the extraction through natural physical changes, eliminating the need for toxic external chemicals while maintaining high extraction efficiency

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method is efficient, cost-effective, non-toxic, and organic, producing chemically stable phytochemical oils with high bioactive compound extraction efficiency.

Implementation Method 1

The aqueous buffer containing the suspended plant powder is incubated with at least one pectinase and at least one cellulase

Methodology Applied
Scientific EffectEnzymatic hydrolysis: Hydrolysis

Implementation Method 2

An aqueous phase of the incubated aqueous buffer is evaporated through steam heating to obtain a steam dried product

Methodology Applied
Scientific EffectEvaporation: Evaporation

Implementation Method 3

An aqueous phase of the incubated aqueous buffer is evaporated through steam heating

Methodology Applied
Scientific EffectThermal energy transfer: Heating

Implementation Method 4

extracting phytochemical oil, which includes at least one of cannabinoids, curcuminoids, and ginsenosides, is extracted from the steam dried product

Methodology Applied
Scientific EffectSupercritical fluid extraction: Supercritical Fluid Extraction

Data Source

PatentUS10946307B2Extraction of cannabinoids, curcuminoids and ginsenosides
Publication Date: 2021.03.16 BRIGHT GREEN CORP
  • US10946307B2 patent drawing

AI summary

An example method for extracting phytochemical oil from plant parts includes freezing plant parts from at least one of Cannabis sativa, Curcuma longa, Panax ginseng, and Panax quinquefolius. The frozen plant parts are reduced to a plant powder, which is suspended in an aqueous buffer. The aqueous buffer containing the suspended plant powder is incubated with at least one pectinase and at least one cellulase. An aqueous phase of the incubated aqueous buffer is evaporated through steam heating to obtain a steam dried product. Phytochemical oil, which includes at least one of cannabinoids, curcuminoids, and ginsenosides, is extracted from the steam dried product.