Phytoecdysone Derivatives for Motor Neuron and Muscle Preservation
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Solution Overview
Problem
Current treatments for neuromuscular diseases like infantile spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are limited in efficacy and safety, particularly due to the lack of therapies that can effectively target both neuronal and muscular alterations, and there is a need for complementary approaches to enhance motor neuron survival and muscular function.
Innovation Solution
The use of phytoecdysones and their semi-synthetic derivatives, such as 20-hydroxyecdysone, to treat neuromuscular diseases by improving motor neuron survival and muscular function through administration in the form of pharmaceutical-grade extracts or derivatives, targeting both neuronal and muscular functions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current symptomatic treatments are used for neuromuscular diseases, then patient care can be provided, but treatment efficacy is limited and cannot address the underlying neuronal and muscular alterations
Solution Approach 1:
The patent applies universality by using phytoecdysones as a multi-functional therapeutic agent that simultaneously targets both neuronal survival and muscular function. The compound acts on multiple systems (nervous and muscular) with a single treatment, addressing the limitation of current symptomatic therapies that can only provide palliative care without resolving underlying pathologies in both tissue types.
2Duration of action of stationary object
If existing therapies are administered, then some motor function can be maintained, but they fail to effectively preserve motor neuron survival and prevent muscular atrophy
Solution Approach 1:
The patent applies preliminary action by administering phytoecdysones to prevent motor neuron degeneration and muscular atrophy before they occur or at early stages. The treatment aims to preserve motor neuron survival and prevent the progression of neuromuscular deterioration rather than merely responding to established damage, thereby extending the duration of motor neuron function and improving therapeutic reliability.
Data Source
AI summary
Disclosed are 20-hydroxyecdysone and the derivatives thereof, intended for use in the treatment of a neuromuscular disease such as spinal muscular atrophy or amyotrophic lateral sclerosis, or more particularly in the treatment of a specific disorder of the motor neurons causing alterations in the muscular function occurring in the context of these neuromuscular diseases.