Phytosterol Composite Formulation for Synergistic Cholesterol Lowering
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Solution Overview
Problem
The increasing prevalence of dyslipidemia and hypercholesterolemia poses a significant risk for cardiovascular diseases, necessitating effective compositions to lower blood lipids and cholesterol.
Innovation Solution
A composition comprising phytosterol, red yeast rice extract, and lycopene in specific weight ratios, optionally with pharmaceutically allowable excipients, formulated into various preparations to address hyperlipidemia and hypercholesterolemia.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If single-component interventions are used to lower blood lipids, then the mechanism is simple, but the efficacy is insufficient and cannot achieve significant lipid reduction
Solution Approach 1:
The patent combines three components (phytosterol, red yeast rice extract, and lycopene) into a single composition to achieve synergistic lipid-lowering effects. This merging of multiple functional components resolves the contradiction by achieving superior efficacy through combination rather than single-component intervention, while maintaining formulation simplicity through integrated delivery.
Solution Approach 2:
The invention creates a composite formulation containing phytosterol, red yeast rice extract, and lycopene in specific ratios. This composite material approach allows the composition to exhibit synergistic effects that individual components cannot achieve alone, thereby improving lipid lowering reliability while managing complexity through standardized formulation.
2Reliability
If multiple components are combined to achieve synergistic effect, then the lipid lowering efficacy is improved, but the formulation complexity increases
Solution Approach 1:
The patent optimizes the weight ratios of the three components (phytosterol: 200-1000 parts, red yeast rice extract: 50-500 parts, lycopene: 10-500 parts) to achieve synergistic effects. By carefully controlling these parameter changes in the formulation, the invention maximizes lipid lowering efficacy while maintaining manufacturability through defined ratio ranges rather than requiring complex multi-step processes.
3Adaptability or versatility
If conventional lipid lowering treatments are used, then the mechanism is well-established, but they cannot address multiple lipid parameters simultaneously
Solution Approach 1:
The composition is designed to simultaneously address multiple lipid parameters including total cholesterol, triglycerides, and LDL cholesterol through the combined action of phytosterol, red yeast rice extract, and lycopene. This multi-functional approach allows a single formulation to control multiple lipid markers, thereby improving adaptability and comprehensive efficacy compared to single-target conventional treatments.
Data Source
AI summary
The present invention relates to the technical field of medicines, and in particular to a composition for lowering blood lipids and cholesterol, a preparation method therefor, and an application thereof. The composition comprises the following components in parts by weight: 200-1000 parts of phytosterol or an analog thereof, 50-500 parts of red yeast rice extract, and 10-500 parts of lycopene. By means of compounding phytosterol or the analog thereof, the red yeast rice extract, and lycopene in the above composition, it was discovered that phytosterol or the analog thereof, the red yeast rice extract, and lycopene have a synergistic effect of lowering blood lipids and cholesterol, can be used to prepare products for lowering blood lipids and cholesterol, and have applications in the preparation of products for the prevention, alleviation, adjunctive treatment, or treatment of hyperlipidemia and/or hypercholesterolemia.