Phytotherapeutic Composition for Osteoarticular Inflammation and Pain
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Solution Overview
Problem
Current treatments for osteoarticular inflammation and pain, such as osteoarthritis, are often poorly tolerated and have insufficient pain reduction, leading to the need for additional painkillers, which can compromise the effectiveness of cartilage recovery treatments.
Innovation Solution
Compositions for oral administration combining Vitis vinifera extract in complex with phospholipids, Punica granatum extract, lipophilic extracts of Zingiber officinale and Zanthoxylum spp., and an unsaponifiable fraction of olive oil or N-acetyl glucosamine or diacerein, which are effective in preventing and treating osteoarticular inflammation and pain by acting on proteoglycan synthesis and inhibition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If non-steroidal anti-inflammatory drugs (NSAIDs) are used for treating osteoarticular inflammation and pain, then pain relief is achieved, but serious side effects occur especially at gastric level and cardiac and vascular level
Solution Approach 1:
The patent uses a multi-component phytotherapeutic composition as an intermediary alternative to NSAIDs. This composition includes extracts from Vitis vinifera (grape), Zingiber officinale (ginger), Zanthoxylum spp. (prickly ash), and other plant sources, combined with chondroprotective agents like glucosamine and chondroitin sulfate. The phytoextracts provide anti-inflammatory and analgesic effects through multiple active compounds (polyphenols, gingerols, zanthoxylum alkaloids) that act on different pathways, achieving pain relief without the gastric and cardiac side effects of conventional NSAIDs.
Solution Approach 2:
The invention employs a composite phytotherapeutic formulation combining multiple plant extracts with specific chondroprotective molecules. The composition integrates: (1) Vitis vinifera extract rich in resveratrol and polyphenols, (2) Zingiber officinale extract containing gingerols and shogaols, (3) Zanthoxylum spp. extract with alkaloids, and (4) chondroprotective agents (glucosamine, chondroitin sulfate). This composite approach provides synergistic anti-inflammatory, analgesic, and cartilage-protective effects while avoiding the harmful side effects of single-molecule NSAIDs.
2Reliability
If OA supplements based on chondroitin sulphate, glucosamine or diacerein are used, then cartilage recovery is promoted, but pain reduction is insufficient forcing patients to use additional painkillers
Solution Approach 1:
The patent merges two previously separate therapeutic approaches into a single integrated formulation: (1) chondroprotective agents (glucosamine, chondroitin sulfate, diacerein) that promote cartilage recovery, and (2) anti-inflammatory/analgesic phytoextracts (Vitis vinifera, Zingiber officinale, Zanthoxylum spp.) that provide pain relief. This combination ensures that patients receive both cartilage-protective effects and sufficient pain reduction, eliminating the need for additional painkillers that would compromise treatment effectiveness.
3Duration of action of stationary object
If classical anti-inflammatories are used at high doses for lengthy treatments, then anti-inflammatory effect is maintained, but serious side effects occur especially at gastric level
Solution Approach 1:
The patent changes the chemical parameters of the anti-inflammatory agents by using natural phytochemicals instead of synthetic NSAIDs. The formulation includes polyphenols from Vitis vinifera, gingerols from Zingiber officinale, and zanthoxylum alkaloids, which provide sustained anti-inflammatory effects over lengthy treatment periods without causing gastric side effects. These natural compounds have different mechanisms of action and safety profiles compared to classical anti-inflammatories, allowing long-term use for chronic osteoarticular conditions.
Data Source
AI summary
The present invention relates to compositions comprising: a) a Vitis vinifera extract in free form or in the form of a complex with phospholipids, or a Punica granatum extract; and b) a lipophilic extract of Zingiber officinale; and c) a lipophilic extract obtained from plants containing polyunsaturated fatty acid isobutylamides selected from the group consisting of Echinacea spp. extract or Zanthoxylum spp. extract or Acmella oleracea (or Spilanthes oleracea) extract; and d) an unsaponifiable fraction of olive oil and/or corn oil; or e) N-acetyl glucosamine; or f) diacerein; and their use in the prevention and/or treatment of osteoarticular inflammation and pain, and cartilage damage.