Piercing-Chamber Assay Device for Rapid Saliva Sample Mixing
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Solution Overview
Problem
Existing rapid diagnostic devices face challenges in efficiently collecting and mixing fluid samples with treatment solutions for on-site analyte detection, particularly in devices like saliva and urine collection, due to issues with suction tips and fluid mixing effectiveness.
Innovation Solution
A device with a movable piercing element and chambers for accommodating treatment solutions and fluid samples, allowing for mixing and transfer of samples to testing elements, facilitated by a movable piercing element that pierces sealed chambers and mixes with absorbing elements to form a mixed solution for analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a traditional suction tip is used to collect and transfer saliva sample, then the collection process is simple, but the mixing effectiveness with treatment solution is poor and detection sensitivity is reduced
Solution Approach 1:
The device is divided into separate functional modules: a collection chamber for saliva sample, a treatment solution reservoir, and a test strip assembly. This segmentation allows each component to perform its specific function optimally - the collection chamber ensures proper mixing, the reservoir provides controlled solution delivery, and the test strip enables accurate detection, thereby improving overall detection sensitivity without creating a monolithic complex structure.
Solution Approach 2:
The treatment solution is pre-loaded into a sealed reservoir, and the collection chamber is prepared in advance with the saliva sample. This preliminary preparation ensures that when mixing occurs, both components are ready and can be combined effectively, improving mixing effectiveness and detection sensitivity before the actual testing process begins.
2Quantity of substance
If the piercing element is fixed in position, then the device structure is simpler, but the ability to mix fluid sample with treatment solution is insufficient
Solution Approach 1:
The piercing element is designed to be movable rather than fixed, allowing it to dynamically pierce the sealed reservoir and enable interaction between the saliva sample and treatment solution. This dynamic capability ensures effective mixing of the two substances while maintaining a relatively simple overall device structure, as the movement mechanism is straightforward and integrated into the device architecture.
3Quantity of substance
If the chamber is opened to allow mixing, then the mixing is more effective, but contamination risk increases
Solution Approach 1:
The treatment solution is pre-loaded into a sealed reservoir before use. This preliminary sealing action prevents contamination of the solution while it is stored, and the piercing mechanism allows controlled opening only when needed for mixing with the saliva sample, thus maintaining sterility until the moment of use.
Solution Approach 2:
The piercing element acts as an intermediary mechanism that allows controlled interaction between the sealed treatment solution reservoir and the saliva sample collection chamber. It enables the necessary fluid mixing while maintaining the seal integrity until the piercing occurs, thereby minimizing contamination risk during the mixing process.
4Productivity
If multiple components are integrated in one device, then the testing process is more efficient, but the device complexity increases
Solution Approach 1:
The device merges multiple essential functions into a single integrated unit: saliva sample collection, treatment solution storage and delivery, mixing chamber, and test strip assembly. This consolidation allows the entire testing process to occur in one device, improving testing efficiency and convenience while the modular design keeps the complexity manageable through functional integration rather than separate components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the sensitivity and accuracy of analyte detection by ensuring effective mixing and transfer of fluid samples with treatment solutions, reducing interference and improving testing performance.
Implementation Method 1
mixes with absorbing elements to form a mixed solution for analysis
Data Source
AI summary
The present disclosure provides a device for testing an analyte in a fluid sample and a receiving device for treating the fluid sample, wherein the receiving device is used for receiving an absorbing element; the receiving device comprises a accommodating chamber and the chamber comprises a piercing element that is movable in the chamber, wherein the piercing element has a first position and a second position in the accommodating chamber, and configured to pierce the first sealed chamber; the accommodating chamber comprises a treatment solution for treating a fluid sample. The assay device and receiving device of the present disclosure treats a sample and quickly obtain the assay result, which is especially suitable for quick assay of a roadside drug.