Pinch Valve Assembly for Reversible Multi-Branch Fluid Routing

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Existing pharmaceutical and bioprocess systems require complex and cumbersome setups with numerous conduits and valves for fluid flow reversal, necessitating frequent sterilization to prevent cross-contamination, and there is a need for a more elegant and compact solution that incorporates flexible, disposable tubing.

Innovation Solution

A valve assembly with a multidirectional flow path featuring a valve body and flexible conduit with a loop portion and branches, utilizing multiple valves to selectively pinch the conduit in different configurations, optionally encapsulated by rigid jackets, allowing for fluid direction in various manufacturing processes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If multiple separate valves and conduits are used for fluid flow reversal, then flow direction control is achieved, but device complexity and sterilization requirements increase

Engineering Contradiction:
Improveflow direction controlVSAvoidnumber of valves and conduits
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent combines multiple valve functions into a single integrated valve body with multiple ports. The valve member can be positioned to direct fluid flow between multiple branches simultaneously, eliminating the need for separate valves for each flow path configuration. This merging approach maintains flow reversal capability while significantly reducing the total number of components.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The single valve body is designed with multi-functionality to handle multiple flow directions and configurations. The valve member can assume different positions to achieve various flow patterns (e.g., forward flow, reverse flow, bypass), making one valve perform the work of multiple specialized valves. This universal design reduces system complexity while maintaining adaptability.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Ease of manufacture

If flexible disposable tubing is used, then sterilization requirements are reduced, but structural support and flow control precision may be compromised

Engineering Contradiction:
Improvesterilization frequencyVSAvoidstructural support
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The flexible conduit is nested within the rigid valve body structure. The valve body provides a stable framework that houses and supports the flexible tubing, ensuring proper positioning and structural integrity. This nested arrangement allows the system to benefit from both the disposability and ease of manufacture of flexible tubing and the structural reliability of rigid components.

Inventive Principle:
Principle #7Nested doll (Nesting)

Solution Approach 2:

The system employs a composite structure combining rigid valve body material (providing structural support and precision) with flexible conduit material (providing ease of manufacture and sterilization advantages). This composite approach allows each material to contribute its strengths, achieving both structural reliability and manufacturing ease.

Inventive Principle:
Principle #40Composite materials

3Volume of moving object

If compact valve assembly is implemented, then space efficiency improves, but holdup volume reduction becomes more challenging

Engineering Contradiction:
Improvevalve assembly sizeVSAvoidfluid holdup volume
Core Design Contradiction:
Volume of moving objectVSLoss of substance

Solution Approach 1:

The valve internal passages are designed with three-dimensional optimization to minimize dead zones and holdup volumes. By carefully designing the spatial arrangement of ports and internal flow paths, the valve achieves compact external dimensions while maintaining efficient fluid flow that minimizes trapped fluid. The dimensional optimization ensures that compactness does not come at the cost of excessive holdup volume.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution provides a compact, efficient, and sterile fluid flow management system that minimizes holdup volumes and facilitates easy replacement of flexible tubing, reducing contamination risks and operational complexity.

Implementation Method 1

Multiple valves are situated on the valve body and are used to selectively pinch the loop portion in different pinching configurations to direct fluid to or from the particular branches

Methodology Applied
Scientific EffectMechanical Force: Mechanical Force

Data Source

PatentUS12460731B2Valve assembly with directional flow path
Publication Date: 2025.11.04 REPLIGEN CORP
  • US12460731B2 patent drawing
  • US12460731B2 patent drawing
  • US12460731B2 patent drawing

AI summary

A valve assembly with a multidirectional flow path includes a valve body that includes respective hinged portions defining respective passageways extending through the valve body when in a closed state. A flexible conduit or tubing having a loop portion and a plurality of branches extending from the loop portion is at least partially positioned within the valve body. Portions of the loop that extend beyond the valve body are encapsulated by respective rigid jackets. Multiple valves are situated on the valve body and are used to selectively pinch the loop portion in different pinching configurations to direct fluid to or from the particular branches. The valve assembly may be integrated into a manufacturing or other production process with optional additional jackets used to encapsulate the flexible conduit branches.