Pioglitazone Coated Preparation Dissolution
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing pharmaceutical preparations containing pioglitazone hydrochloride often face challenges with preservation stability and dissolution properties, particularly in releasing the active ingredient effectively within a short timeframe.
Innovation Solution
A production method involving coating pioglitazone hydrochloride with an aqueous dispersion using a coating material of low viscosity, such as hydroxypropyl cellulose or polyvinyl alcohol-polyethylene glycol graft copolymer, to enhance dissolution properties, ensuring at least 50% release within 15 minutes in dissolution tests.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional coating materials with high viscosity are used, then the coating process is easier to handle, but the dissolution property of pioglitazone hydrochloride deteriorates
Solution Approach 1:
The patent applies parameter changes by selecting coating materials with specifically controlled low viscosity (≤35 mPa·s at 20°C in 5% aqueous solution) to resolve the contradiction between ease of operation and dissolution property. This parameter specification enables both manageable coating processes and superior dissolution characteristics (≥50% release within 15 minutes).
Solution Approach 2:
The patent employs composite materials by combining pioglitazone hydrochloride with specific low-viscosity coating materials (hydroxypropyl cellulose SL/SSL or polyvinyl alcohol-polyethylene glycol graft copolymer) to create a coated preparation that achieves both operational feasibility and enhanced dissolution performance.
2Manufacturing precision
If coating material viscosity is reduced to improve dissolution, then the coating process becomes more difficult to control
Solution Approach 1:
The patent resolves this contradiction by establishing a specific viscosity parameter range (≤35 mPa·s at 20°C for 5% aqueous solution) that balances dissolution performance with coating process controllability, demonstrating that precise parameter control can simultaneously achieve both goals.
3Manufacturing precision
If conventional formulations are used, then preservation stability is compromised, but modifying the formulation improves dissolution properties
Solution Approach 1:
The patent applies composite materials by formulating pioglitazone hydrochloride with specific low-viscosity coating materials (hydroxypropyl cellulose SL/SSL or polyvinyl alcohol-polyethylene glycol graft copolymer) to simultaneously achieve superior dissolution properties (≥50% release within 15 minutes) and improved preservation stability.
Data Source
AI summary
The present invention provides a production method of a preparation coated with pioglitazone hydrochloride, which is useful as a therapeutic agent for diabetes and the like, and which is superior in the characteristics of the preparation such as dissolution property of pioglitazone hydrochloride.