Pipette Alignment Fixture for Consistent Particle Withdrawal
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Solution Overview
Problem
Manual pipetting of solutions containing particles results in inconsistent and inaccurate assay outcomes due to variability in pipette positioning and operator-dependent withdrawal, leading to inconsistent particle counts and types.
Innovation Solution
A pipette alignment device and method that stabilizes the pipette and positions the pipette tip at predetermined depths within a vial, ensuring consistent agitation and withdrawal of particles, thereby reducing variability between assays and operators.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If manual pipetting is used, then operator flexibility and ease of operation are maintained, but pipette positioning consistency and particle withdrawal accuracy deteriorate
Solution Approach 1:
The patent introduces a physical alignment system with guide structures, positioning fixtures, and depth markers that act as intermediaries between the operator and the pipette. These fixtures mechanically guide the pipette to predetermined positions and depths, eliminating manual positioning variability while preserving operator control over the withdrawal process itself.
2Reliability
If fixed pipette positioning is implemented, then particle withdrawal consistency is improved, but device complexity increases
Solution Approach 1:
The alignment system is segmented into distinct functional components: vertical positioning fixtures, horizontal alignment guides, depth markers, and clamping mechanisms. Each component addresses a specific aspect of positioning, allowing the system to achieve high consistency through modular, manageable elements rather than a single complex mechanism.
3Manufacturing precision
If automated pipetting is used, then positioning precision is improved, but ease of operation and adaptability deteriorate
Solution Approach 1:
The alignment fixtures are designed to be self-aligning and self-positioning. Once the operator places the pipette in the general area, the mechanical guides and fixtures automatically constrain it to the precise predetermined position and depth, eliminating the need for complex automated control systems while maintaining both precision and operator control.
Data Source
AI summary
A device comprising a base and a support structure is disclosed. The base includes a vial receptacle for holding a vial. The support structure is coupled to an upper portion of the base and is configured to align a pipette comprising a pipette tip vertically over the vial receptacle. The support structure is configured to support a pipette such that an end of a pipette tip is positioned one or more predetermined depths within a vial in the vial receptacle.