Pipetting Control for Continuous Multi-Liquid Volume Accuracy
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing automated analysis devices face challenges in accurately delivering a target pipetting amount when continuously sucking and discharging multiple types of liquids, as residual liquid amounts vary due to the order of suction and physical properties, leading to reduced analysis accuracy.
Innovation Solution
The device incorporates a pipetting mechanism with a control unit that adjusts the extra suction amount based on the order of liquid suction and physical properties to ensure accurate delivery of each liquid to a reaction container, using a combination of target and extra suction amounts to compensate for residual liquid.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the pipetting mechanism continuously sucks and discharges multiple types of liquids to reduce washing times and shorten pipetting time, then productivity is improved, but manufacturing precision deteriorates because residual liquid amounts vary due to suction order
Solution Approach 1:
The control unit pre-calculates and sets the extra suction amount for each liquid based on its suction order and physical properties before the pipetting operation begins. This preliminary adjustment ensures that the target pipetting amount is achieved despite variations in residual liquid, resolving the contradiction between high-speed continuous pipetting and precise volume delivery.
Solution Approach 2:
The system changes the suction parameter (extra suction amount) dynamically based on the suction order and physical properties of each liquid. By adjusting this parameter, the system compensates for the varying residual liquid amounts that occur during continuous multi-liquid pipetting, maintaining precision while preserving high productivity.
2Manufacturing precision
If the pipetting mechanism sucks an extra suction amount to compensate for residual liquid, then manufacturing precision is improved, but loss of substance increases
Solution Approach 1:
The control unit applies a localized extra suction amount to each specific liquid based on its individual characteristics (suction order and physical properties) rather than using a uniform extra amount for all liquids. This targeted approach minimizes liquid waste while ensuring each liquid reaches its target pipetting amount accurately.
Solution Approach 2:
The system uses a controlled excessive suction action (extra suction amount) that is partially more than the target amount, then adjusts by varying the extra amount based on suction order. This allows precise compensation for residual liquid without excessive waste, as the extra suction is optimized for each liquid rather than being uniformly excessive.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach ensures high analysis accuracy by precisely delivering the intended pipetting amount, minimizing residual liquid in the pipetting mechanism, thereby enhancing the reliability of biochemical and gene analysis.
Implementation Method 1
a pipetting mechanism that sucks a liquid from a specimen container or a reagent container and discharges the liquid to a reaction container
Data Source
AI summary
The automated analysis device according to the present invention includes a pipetting mechanism that sucks a liquid from a specimen container or a reagent container and discharges the liquid to a reaction container, and a control unit that controls an operation of the pipetting mechanism to pipette a target pipetting amount of a liquid, wherein in pipetting, the pipetting mechanism sucks an extra suction amount of a liquid in addition to the target pipetting amount of the liquid, and when the pipetting mechanism is to continuously suck a plurality of types of liquids and continuously discharge the plurality of types of liquids that have been sucked, the control unit varies an extra suction amount to be sucked by the pipetting mechanism according to an order of sucking liquids.