Pistachio Melatonin Composition With Herbal Matrix Bioavailability
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Solution Overview
Problem
There is a need for a plant-based source of melatonin that provides a consistent and effective dose for regulating sleep, as synthetic melatonin is subject to quality variation and animal-derived sources are associated with health concerns.
Innovation Solution
A method for enriching Pistachio seed kernels to extract a melatonin-enriched composition, bound with complex herbal matrices, which includes arginine, tryptophan, lutein, and resveratrol, to enhance bioavailability and effectiveness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If synthetic melatonin is used, then melatonin is available for sleep regulation, but quality variation occurs and bioavailability is limited to approximately 15%
Solution Approach 1:
The patent changes the source parameter from synthetic to plant-based (Pistacia vera), and modifies the delivery form parameter by binding melatonin with complex herbal matrices containing arginine, tryptophan, lutein, and resveratrol. These parameter changes aim to improve both quality consistency and bioavailability compared to synthetic melatonin
2Ease of manufacture
If animal-derived melatonin is used, then melatonin can be produced, but health concerns arise from animal origin
Solution Approach 1:
The patent extracts melatonin from plant-based Pistacia vera seeds instead of using animal-derived sources. This extraction from plant material eliminates the health concerns associated with animal origin while maintaining production availability
Solution Approach 2:
The patent creates a composite material by binding plant-derived melatonin with complex herbal matrices containing multiple compounds (arginine, tryptophan, lutein, resveratrol). This composite approach provides a safe plant-based alternative to animal-derived melatonin
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Pistachio-derived melatonin extract increases melatonin activity on MT1 and MT2 receptors, providing a synergistic effect for treating sleep conditions with improved absorption and efficacy compared to synthetic melatonin.
Implementation Method 1
a melatonin-enriched composition of Pistacia vera (pistachio) and a method of preparation thereof
Data Source
AI summary
Provided herein are methods and compositions for a melatonin-enriched composition of Pistacia vera (Pistachio).