Placental Stem Cell Survival via Gene Modulation

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Mammalian placentas, typically discarded as medical waste, contain valuable stem cells that face reduced survival due to environmental insults, necessitating the development of placental stem cells resistant to conditions leading to cell death.

Innovation Solution

Modification of placental stem cells using oligomeric or polymeric molecules, such as modulatory RNA molecules, to inhibit or upregulate specific genes associated with survival, enhancing their resistance to conditions that would normally cause cell death, including exposure to serum, complement, and immune cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If placental stem cells are exposed to environmental factors (serum, complement, immune cells), then therapeutic applications can be pursued, but cell survival decreases due to environmental insults

Engineering Contradiction:

Improvecell survivalVSAvoidenvironmental insults

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies preliminary action by pre-modifying placental stem cells with oligomeric or polymeric molecules before exposure to adverse environmental conditions. This preliminary modification enables the cells to resist harmful factors such as serum, complement, and immune cells, thereby improving survival rates during subsequent therapeutic applications.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent converts harmful environmental factors into beneficial outcomes by using oligomeric or polymeric molecules to transform the cells' vulnerability into resistance. The modification process enables the cells to withstand previously harmful conditions, turning environmental insults into opportunities for successful therapeutic delivery and engraftment.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Reliability

If placental stem cells are modified with oligomeric or polymeric molecules to enhance survival, then resistance to cell death conditions improves, but molecular complexity increases

Engineering Contradiction:

Improveresistance to cell deathVSAvoidmolecular complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies parameter changes by modifying the physical or chemical properties of placental stem cells through the introduction of oligomeric or polymeric molecules. These parameter changes enhance the cells' resistance to death conditions while managing molecular complexity through targeted modifications rather than comprehensive restructuring.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS20230081199A1Enhanced placental stem cells and uses thereof

Publication Date: 2023.03.16 CELENIV PTE LTD

AI summary

Provided herein are placental stem cells that exhibit increased survival (“enhanced placental stem cells”), compositions comprising such placental stem cells, and methods of using such placental stem cells and compositions.