Planar Microfluidic Strip Chip for Multi-Indicator Detection
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Solution Overview
Problem
Current microfluidic detection strip technologies face challenges in cost-effectiveness and complexity due to three-dimensional structures, limiting their widespread use in medical detection, as they are expensive and difficult to produce, and existing spraying technologies are inadequate for detecting multiple indicators efficiently.
Innovation Solution
A microfluidic detection strip chip with a planar structure microfluidic pipe bonded to a substrate, where the flow rate and direction of samples or reagents are controlled through micro tube valves, allowing precise placement of reagent blocks based on target molecular weights, enabling efficient detection of multiple indicators with reduced sample consumption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If three-dimensional microfluidic pipe structure is used, then accurate infiltration of micro samples or reagents into reagent blocks is achieved, but device complexity and production cost increase significantly
Solution Approach 1:
The patent transforms the three-dimensional microfluidic pipe structure into a planar two-dimensional structure. The microfluidic pipe is designed with a flat bottom surface that bonds directly to the substrate, eliminating the need for complex 3D routing while maintaining fluid control functionality through planar channels and chambers.
Solution Approach 2:
The microfluidic pipe is divided into multiple independent functional modules including sample adding component, reagent adding component, reaction chambers, and flow control valves. Each module can be independently designed, manufactured, and assembled, reducing overall system complexity while maintaining infiltration precision.
2Manufacturing precision
If three-dimensional microfluidic pipe structure is used, then accurate infiltration of micro samples or reagents into reagent blocks is achieved, but production cost increases making it unsuitable for popularization
Solution Approach 1:
By flattening the microfluidic pipe structure into a planar configuration, the manufacturing process becomes simpler and more suitable for mass production. The planar structure can be fabricated using standard planar fabrication techniques rather than complex 3D printing or assembly processes, significantly reducing production costs.
Solution Approach 2:
The microfluidic pipe structure is merged directly with the substrate through bonding, eliminating the need for separate complex 3D components. This integration reduces the number of parts, simplifies assembly, and lowers manufacturing costs while maintaining the required infiltration precision.
3Loss of substance
If conventional spraying technology is used to soak test strips, then sample consumption is reduced, but the ability to detect multiple indicators efficiently is insufficient
Solution Approach 1:
The detection system is segmented into multiple independent reagent blocks, each capable of detecting different indicators. The microfluidic pipe distributes sample fluid to multiple reaction chambers simultaneously, enabling parallel detection of hundreds of indicators while maintaining low sample consumption through precise microfluidic control.
Solution Approach 2:
The microfluidic pipe structure serves multiple functions: it controls fluid flow, distributes sample to multiple reagent blocks, regulates flow rate through valves, and enables simultaneous detection of multiple indicators. This multi-functionality achieves both low sample consumption and high detection efficiency for multiple indicators.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach simplifies the production process, reduces costs, and allows for the detection of hundreds to thousands of indicators, improving detection efficiency and reducing waste, while ensuring precise sample and reagent infiltration, thus enhancing the popularization of microfluidic technology in medical detection.
Implementation Method 1
The capillary network forms a plurality of grooves arranged in a lattice pattern on the substrate, each groove is connected with the capillary net through a second port
Implementation Method 2
a flow rate and flow direction of samples or reagents entering the reagent block are controlled by changing a size of a micro tube valve
Implementation Method 3
The reagent block comprises a reaction part and a waste liquid absorption part for sample and/or reagent color reaction
Implementation Method 4
the sample hole comprises a first filter screen configured to filter large particle components in a liquid sample
Data Source
AI summary
A microfluidic detection strip chip for multiple indicator detection of microsample and method thereof are disclosed. The microfluidic detection strip chip includes a substrate, a plurality of microfluidic pipes, and a plurality of reagent blocks, the microfluidic pipes and the reagent blocks arranged in a lattice are arranged on the substrate for detection of enzyme, chemistry, protein, polypeptide, amino acid, nucleic acid, and exocrine components in samples. The microfluidic pipes and reagent blocks are made using micro processing technology, and the reagent blocks are printed to the lattice array grooves constructed by the substrate and microfluidic pipes, thus realizing an analysis and detection effect of multiple indicators of microsample.