Plant-Based Compound Formulation for Faster Oral Absorption
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Solution Overview
Problem
Plant-based compounds and nutritional supplements administered orally exhibit slow onset of action and low bioavailability due to poor aqueous solubility and first-pass hepatic metabolism, limiting their effectiveness in certain applications.
Innovation Solution
Formulating plant-based compositions with N-acylated fatty amino acids and absorption-enhancing agents such as surfactants, detergents, azones, pyrrolidones, glycols, and bile salts to enhance absorption and bioavailability, resulting in faster onset and increased therapeutic efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If plant-based compounds are administered orally in conventional formulations, then they are easier to administer and more acceptable to patients, but they exhibit slow onset of action and low bioavailability
Solution Approach 1:
The patent uses N-acylated fatty amino acids as intermediary carriers that facilitate the transport of plant-based compounds across the gastrointestinal tract and intestinal barrier. These carriers act as mediators between the orally administered plant compounds and the systemic circulation, enabling faster absorption without requiring alternative administration routes
Solution Approach 2:
The patent modifies the chemical parameters of the formulation by using N-acylated fatty amino acids with specific molecular weights, hydrophobicity, and structural characteristics. These parameter changes in the carrier molecules enable them to enhance the permeability and absorption rate of plant-based compounds, transforming the slow-absorbing oral formulation into a fast-acting delivery system
2Ease of operation
If plant-based compounds are administered orally in conventional formulations, then they are easier to administer, but they exhibit low bioavailability due to poor aqueous solubility and first-pass hepatic metabolism
Solution Approach 1:
N-acylated fatty amino acids serve as intermediary carriers that protect plant-based compounds from degradation by digestive enzymes and first-pass hepatic metabolism. The carrier molecules facilitate direct absorption into the bloodstream, bypassing the metabolic pathways that would otherwise reduce bioavailability
Solution Approach 2:
The patent creates composite formulations where plant-based compounds are combined with N-acylated fatty amino acids in specific ratios. This composite material approach leverages the complementary properties of both components: the therapeutic activity of plant compounds and the absorption-enhancing, solubility-improving properties of the N-acylated fatty amino acid carriers
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation leads to increased absorption, faster onset of action, higher peak concentrations, and improved bioavailability of plant-based compounds, enhancing their therapeutic benefits.
Implementation Method 1
N-acylated fatty amino acids, absorption enhancing agents, and/or various other beneficial carriers... increased absorption... increased bioavailability
Implementation Method 2
penetration enhancers... faster onset of action... higher peak concentrations
Data Source
AI summary
Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.