Plant Extract Composition for Statin-Free Cholesterol Reduction
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current pharmacological treatments for hypercholesterolemia, such as statins, have significant side effects and are not suitable for all patients, particularly those resistant or intolerant to statins, and there is a need for alternative strategies to manage mild or moderate cardiovascular risk factors.
Innovation Solution
A composition comprising extracts from the genus Malus, Olea Europaea, and policosanols, which synergistically reduce plasma cholesterol levels, increase HDL levels, and decrease lipid peroxidation, providing a safe and effective alternative to statins.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If statins are used to reduce LDL levels, then cholesterol reduction is achieved, but side effects occur in muscles and liver
Solution Approach 1:
The patent replaces long-term statin therapy with a natural compound composition that achieves cholesterol reduction without the cumulative toxic effects of pharmaceutical statins. The composition uses naturally occurring substances (polysaccharides, polyphenols, sterols) that are metabolized and eliminated without persistent harmful accumulation in muscles and liver.
Solution Approach 2:
The invention employs a composite composition containing multiple natural components (polysaccharides from Malus genus, polyphenols from Olea europaea, and plant sterols) that work synergistically to reduce cholesterol. This composite approach provides efficacy similar to statins while avoiding their harmful side effects through the use of biocompatible natural substances.
2Reliability
If statins are prescribed to high-risk patients, then cardiovascular risk is reduced, but treatment resistance and intolerance develop
Solution Approach 1:
The patent changes the chemical and biological parameters of the treatment by replacing synthetic statins with natural compounds having different molecular structures and mechanisms of action. The composition contains polysaccharides, polyphenols, and sterols that interact with cholesterol metabolism through pathways different from HMG-CoA reductase inhibition, thereby avoiding resistance development associated with statin polymorphisms.
Solution Approach 2:
The natural composition leverages the body's own metabolic pathways and natural regulatory mechanisms to reduce cholesterol. The plant-derived compounds work with endogenous systems rather than forcing external chemical interventions, reducing the likelihood of immune-mediated intolerance and resistance phenomena.
3Ease of operation
If lifestyle changes are recommended for mild-risk patients, then intervention is avoided, but cholesterol levels remain uncontrolled
Solution Approach 1:
The patent provides a natural composition that can be incorporated into daily diet or taken as supplements, offering an easy-to-administer solution that bridges between lifestyle changes and pharmaceutical intervention. The composition uses readily available natural substances that do not require complex administration protocols.
Data Source
AI summary
The present invention relates to a composition comprising an extract of a plant belonging to the genus Malus, an extract of Olea Europaea and policosanols and to the use thereof in reducing plasma cholesterol levels and cardiovascular risk.