Plant Extract Composition for Hyperlipidemia Treatment
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Solution Overview
Problem
The complexity of traditional Chinese medicine compositions like 'Compound Zhenzhu Tiaozhi' makes it difficult to quantify active ingredients and control quality, affecting the stability and clinical efficacy of pharmaceutical preparations for hyperlipidemia treatment.
Innovation Solution
A composition of plant extracts comprising oleanolic acid, salvianolic acid, danshensu, berberine, panax notoginseng saponins, polysaccharides of Atractylodes macrocephala, aucubin, total flavones from Cirsium japonicum, finger citron polysaccharides, and panax notoginseng polysaccharides, which can be formulated into various pharmaceutical preparations and health foods, enhancing bioavailability and purity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional Chinese medicine compositions like 'Compound Zhenzhu Tiaozhi' are used, then clinical efficacy for hyperlipidemia treatment is achieved, but the complexity of composition makes it difficult to quantify active ingredients and control quality
Solution Approach 1:
The patent extracts the active ingredients from the traditional Chinese medicine composition and identifies them as specific chemical compounds (berberine, oleanolic acid, ursolic acid, etc.). This extraction approach allows for quantification and quality control of the active components while maintaining the therapeutic effects of the original formulation.
Solution Approach 2:
The patent establishes specific content ranges for each active ingredient (e.g., berberine 0.5-2.0%, oleanolic acid 0.3-1.5%) to standardize the composition. By defining precise parameter ranges for active ingredients, the patent transforms the complex traditional medicine into a controllable pharmaceutical preparation with consistent quality and efficacy.
2Reliability
If traditional Chinese medicine compositions are used, then blood lipid regulation and anti-atherogenic ability are achieved, but the active ingredient is not clear and difficult to quantify
Solution Approach 1:
The patent extracts and identifies specific active ingredients from the herbal mixture, including berberine, oleanolic acid, ursolic acid, and other compounds. This extraction enables precise measurement and quantification of each active component, transforming the unclear mixture into a well-defined pharmaceutical composition with measurable parameters.
Solution Approach 2:
The patent replaces the traditional herbal medicine system with a modern pharmaceutical system that uses chromatography and spectroscopy methods to identify and quantify active ingredients. This substitution allows for precise measurement of chemical compounds rather than relying on traditional herbal identification methods.
3Reliability
If traditional Chinese medicine compositions are used, then therapeutic effects are achieved, but the quality of products is difficult to obtain effective control
Solution Approach 1:
The patent establishes specific content ranges for each active ingredient to standardize the product quality. By defining precise parameters such as berberine content (0.5-2.0%), oleanolic acid (0.3-1.5%), and ursolic acid (0.3-1.5%), the patent enables effective quality control during manufacturing while maintaining the therapeutic effects of the original traditional medicine.
Solution Approach 2:
The patent implements quality control mechanisms that monitor and adjust the content of active ingredients during production. By establishing feedback loops that ensure each batch meets the specified content ranges, the patent achieves consistent product quality and reliable therapeutic effects across different manufacturing batches.
4Reliability
If traditional Chinese medicine compositions are used, then clinical efficacy is achieved, but the formulations of the pharmaceutical preparations can not be various with limited application range
Solution Approach 1:
The patent creates a universal base formulation containing the identified active ingredients that can be adapted into various pharmaceutical forms including tablets, capsules, granules, and injections. This multi-functional approach allows the same active ingredient combination to serve multiple therapeutic purposes and be delivered through different administration routes, expanding the application range while maintaining clinical efficacy.
Data Source
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AI summary
The present invention relates to a composition of extracts from plants which can be used for prophylaxis or treatment of metabolism disorder of blood lipid, which belongs to the pharmaceutical technology. The plant extract composition provided by the present invention includes the following ingredients in weight: 3-10 portions of oleanolic acid, 1-5 portions of salvianolic acid, 1-5 portions of danshensu, 1-3 portions of berberine, 1-5 portions of panax notoginseng saponins, 1-5 portions of polysaccharides of atracty-lodes macrocephala koidz, 1-3 portions of aucubin, 1-5 portions of total flavone in cirsium japonicum, 1-5 portions of fmger citron polysaccharide, 1-5 portions of panax notoginseng polysaccharides and 1-5 portions of flavones. The present invention also provides the use of such composition in manufacturing medicaments used for prophylaxis or treatment of diseases related to metabolism disorder of blood lipid, and the use of such composition in manufacturing health food used for adjuvant prophylaxis or treatment of diseases related to metabolism disorder of blood lipid. The plant extract composition provided by the present invention has broadened the application of the existing technology in the field of pharmaceutical preparations, which significantly improves the bioavailability, increase the effectiveness, stability, controllability, convenience and safety of medication.