Plant Extract Mixture Reduces Neurotoxicity in Alzheimer's Treatment
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Solution Overview
Problem
Current treatments for Alzheimer's disease only manage symptoms and have significant side effects, with no curative options available, and existing therapeutic agents like AT000 extract are compromised due to the unavailability of Dryobalanops aromatica in the French pharmacopeia.
Innovation Solution
A composition comprising extracts from a mixture of Syzygium aromaticum, Santalum album, Aquilaria malaccensis, Boswellia carterii, Cyperus rotundus, Styrax benzoin, Liquidambar orientalis, and Cinnamomum camphora, with Saussurea costus, which reduces neurotoxicity similar to AT000 extract, is developed, allowing for a novel food-recognized composition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If AT000 extract is used to reduce neurotoxicity, then therapeutic effect is improved, but availability is worsened due to Dryobalanops aromatica not being listed in the French pharmacopeia
Solution Approach 1:
The patent extracts and removes the problematic ingredient Dryobalanops aromatica from the original AT000 extract formulation, creating a modified extract that eliminates the availability issue while retaining the neuroprotective properties through the remaining plant components
Solution Approach 2:
The patent combines multiple plant extracts (Syzygium aromaticum, Santalum album, Aquilaria malaccensis, Boswellia carterii, Cyperus rotundus, Styrax benzoin, Liquidambar orientalis, and Cinnamomum camphora) into a synergistic formulation that collectively provides the therapeutic effect previously achieved by the unavailable AT000 extract
2Ease of operation
If conventional Alzheimer's drugs are used to manage symptoms, then ease of operation is improved, but harmful factors are worsened due to significant side effects
Solution Approach 1:
The patent uses natural plant extracts that possess inherent neuroprotective properties to counteract the harmful side effects of conventional drugs, converting the therapeutic approach from synthetic chemistry to natural medicine to eliminate adverse reactions while maintaining symptom management capability
Solution Approach 2:
The patent changes the chemical composition parameters from synthetic pharmaceutical compounds to natural plant-derived substances, fundamentally altering the therapeutic agent's properties to eliminate side effects while preserving neuroprotective function
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The new composition effectively reduces neurotoxicity induced by the Aβ 25-35 peptide, improving cognitive performance and oxidative stress in mouse models, offering a potential therapeutic alternative for Alzheimer's disease with reduced side effects.
Implementation Method 1
the optimization of the antioxidant activity (DPPH test, activity of trapping the radicals of the extract) of different formulas
Implementation Method 2
activity of trapping the radicals of the extract
Data Source
AI summary
The present invention relates to the pharmaceutical and nutraceutical fields and, more specifically, to a composition comprising an extract from a combination of plants for the prevention and/or treatment of a neurodegenerative disease