Natural Plant Extract Composition for Prostate Disease Treatment
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Solution Overview
Problem
Current treatments for benign prostatic hyperplasia, such as 5α-reductase inhibitors, have limitations including long onset of effects, side effects like dizziness and erectile dysfunction, and dependence on imported synthetic compounds, necessitating the development of new natural product drugs.
Innovation Solution
A pharmaceutical and health functional food composition containing extracts of Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora, which inhibit 5α-reductase activity, potentially offering a safer and more effective alternative for treating benign prostatic hyperplasia.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If 5α-reductase inhibitors (finasteride, dutasteride) are used to treat benign prostatic hyperplasia, then the prostate size is reduced and disease progression is slowed, but side effects such as dizziness, fatigue, erectile dysfunction, and loss of sexual desire occur
Solution Approach 1:
The patent replaces expensive imported synthetic 5α-reductase inhibitors with a domestically available natural product composition containing Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora extracts. This natural composition achieves comparable therapeutic effectiveness while avoiding the severe side effects associated with synthetic inhibitors, providing a safer long-term treatment option for benign prostatic hyperplasia
Solution Approach 2:
The patent uses a composite natural product formulation combining three different plant extracts (Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora) that work synergistically to inhibit 5α-reductase activity. This composite approach provides effective prostate disease treatment while minimizing side effects, as the natural compounds are better tolerated by the body compared to synthetic inhibitors
2Reliability
If synthetic 5α-reductase inhibitors are used for long-term treatment, then disease progression is reduced, but the onset of therapeutic effects is delayed and the treatment duration is extended
Solution Approach 1:
The patent changes the chemical composition parameters from synthetic compounds to natural plant extracts with similar 5α-reductase inhibitory activity. The natural composition maintains effective concentrations of active compounds that can achieve therapeutic effects with potentially faster onset while providing sustained disease control over the long term
3Reliability
If imported 5α-reductase inhibitors are used, then therapeutic effectiveness is achieved, but the cost burden on the national economy increases
Solution Approach 1:
The patent replaces expensive imported synthetic 5α-reductase inhibitors with a domestically available natural product composition containing Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora extracts. This natural composition achieves comparable therapeutic effectiveness while avoiding the severe side effects associated with synthetic inhibitors, providing a safer long-term treatment option for benign prostatichyperplasia
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The complex extract of Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora demonstrates significant 5α-reductase inhibitory activity, reducing the risk of side effects associated with synthetic compounds and providing a cost-effective, natural treatment option for benign prostatic hyperplasia.
Implementation Method 1
Testosterone 5α-reductase converts testosterone, one of the male hormones, to dihydrotestosterone (DHT), an active male hormone... The complex extract of Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora has an effect of inhibiting the activity of 5α-reductase
Data Source
AI summary
The present invention relates to a composition for preventing, treating or improving a prostate disease containing Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora extracts as an active ingredient. According to the present invention, the complex extract of Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora has an effect of inhibiting the activity of 5α-reductase associated with benign prostatic hyperplasia and has an advantage of having a few or no side effects of reducing a male sexual function by using a synthetic compound in the related art using ingredients derived from natural plants. Further, it is confirmed that in a complex extract obtained by mixing Acanthopanax sessiliflorus, Phragmites rhizome, and Pinus densiflora extracts at a more proper ratio, the 5α-reductase inhibitory activity is significantly excellent.