Plant Extract Composition for Inflammation and Skin Barrier Repair
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Solution Overview
Problem
Current treatments for chronic inflammatory skin disorders, such as atopic dermatitis, psoriasis, and acne vulgaris, are limited by side effects and long-term safety concerns, particularly with topical corticosteroids and systemic agents, and there is a need for compositions that address structural degradation of the skin barrier, inflammation, and oxidative stress.
Innovation Solution
A skincare composition comprising a synergistic blend of Calendula officinalis, Symphytum officinale, and biotech-derived Haberlea rhodopensis extracts, optionally with humectants and ceramides, to treat and manage symptoms of inflammatory skin disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If topical corticosteroids are used to treat inflammatory skin disorders, then inflammation is reduced, but side effects and long-term safety concerns increase
Solution Approach 1:
The patent replaces long-term corticosteroid use with a natural ingredient composition that can be used repeatedly without accumulating harmful effects. The composition uses plant-derived extracts (Calendula, Symphytum, Haberlea) that provide anti-inflammatory benefits without the progressive side effects of corticosteroids, allowing for sustained long-term treatment safety.
Solution Approach 2:
The patent employs a composite formulation combining multiple natural extracts (Calendula officinalis, Symphytum officinale, Haberlea rhodopensis) with specific lipids and humectants. This composite approach synergistically addresses inflammation, skin barrier repair, and hydration simultaneously, providing comprehensive treatment that reduces reliance on single-ingredient corticosteroid therapies.
2Object-affected harmful factors
If current treatments are used to manage inflammatory skin disorders, then symptoms are addressed, but structural degradation of the skin barrier is not effectively repaired
Solution Approach 1:
The patent divides the treatment approach into three distinct functional components: (1) anti-inflammatory agents (natural extracts), (2) skin barrier repair agents (ceramides, cholesterol, fatty acids), and (3) hydration agents (humectants). This segmentation allows each component to specifically address its target function, ensuring comprehensive care that simultaneously manages symptoms and repairs structural degradation.
Solution Approach 2:
The patent changes the chemical composition parameters of the skin barrier by supplying exogenous lipids (ceramides, cholesterol, fatty acids) that mimic and replenish the natural skin barrier components. This parameter change restores the lipid matrix structure, improving barrier integrity and stability while addressing the underlying structural degradation rather than just surface symptoms.
3Object-affected harmful factors
If conventional treatments are applied, then inflammation is suppressed, but oxidative stress from reactive oxygen species is not mitigated
Solution Approach 1:
The patent converts the harmful effect of oxidative stress into a beneficial treatment target by incorporating antioxidant-rich natural extracts. The Haberlea rhodopensis and other plant extracts contain phenolic compounds and vitamins that scavenge reactive oxygen species, transforming the approach from merely suppressing inflammation to actively neutralizing the oxidative stress that drives chronic inflammation and skin damage.
Data Source
Figure 1
AI summary
The present invention is directed to compositions and methods for treating and managing symptoms associated with inflammatory skin disorders by applying a synergistic blend of plant-based actives containing at least: (a) Calendula officinalis stem cell extract; (b) Symphytum officinale extract; and (c) a biotech-derived Haberlea rhodopensis extract.