Plant Extract Mesenchymal Stem Cell Attractant for Tissue Targeting
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Solution Overview
Problem
Current differentiation inducers for mesenchymal stem cells are inadequate in attracting bone marrow-derived mesenchymal stem cells to specific tissues within the body via the bloodstream.
Innovation Solution
A mesenchymal stem cell attractant comprising extracts from the Bodhi tree, Paeonia suffruticosa Andrews, Mallotus philippinensis, Uncaria gambir, and Prunus plants, which are used to attract mesenchymal stem cells through chemotaxis, with preferred extraction methods and solvents enhancing their effectiveness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional differentiation inducers (e.g., PDGF-BB) are used to differentiate mesenchymal stem cells into specific tissue cells, then the differentiation capability is improved, but the ability to attract mesenchymal stem cells to specific tissues via the bloodstream is insufficient
Solution Approach 1:
The patent combines differentiation inducer functionality with chemotactic attraction capability into a single composition. The plant extract contains compounds that simultaneously induce mesenchymal stem cell differentiation into specific tissue cells and attract these cells to target tissues through chemotaxis, eliminating the need for separate differentiation and attraction agents.
Solution Approach 2:
The plant extract composition performs multiple functions: it acts as both a differentiation inducer (guiding stem cells to become specific tissue cells) and a chemotactic attractant (guiding stem cell migration to target tissues). This multi-functional agent replaces conventional single-function differentiation inducers that lacked attraction capabilities.
2Ease of operation
If plant extracts are used as mesenchymal stem cell attractants, then the attraction effect is improved, but the differentiation induction capability may be reduced compared to conventional agents
Solution Approach 1:
The patent combines differentiation inducer functionality with chemotactic attraction capability into a single composition. The plant extract contains compounds that simultaneously induce mesenchymal stem cell differentiation into specific tissue cells and attract these cells to target tissues through chemotaxis, eliminating the need for separate differentiation and attraction agents.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The attractant effectively attracts mesenchymal stem cells, as demonstrated by chemotaxis assays, facilitating their accumulation in targeted tissues for potential tissue repair and differentiation.
Implementation Method 1
A mesenchymal stem cell attractant comprising extracts from the Bodhi tree, Paeonia suffruticosa Andrews, Mallotus philippinensis, Uncaria gambir, and Prunus plants, which are used to attract mesenchymal stem cells through chemotaxis
Data Source
AI summary
The present invention aims to provide a mesenchymal stem cell attractant capable of attracting a mesenchymal stem cell; and others. The present invention provides a mesenchymal stem cell attractant containing at least one selected from the group consisting of an extract of a Bodhi tree, an extract of the root bark of Paeonia suffruticosa Andrews, an extract of Mallotus philippinensis, an extract of Uncaria gambir an extract of Pashanbheda, and an extract of a plant belonging to the genus Prunus.