Marcgraviaceae and Platanaceae Plant Extracts for Cortisol Reduction
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Solution Overview
Problem
Current treatments for anxiety and elevated glucocorticoid-related disorders, such as PTSD and hypercortisolism, often have limited efficacy and are associated with significant side effects, while existing herbal remedies may not fully address the underlying physiological responses to stress and anxiety.
Innovation Solution
A composition comprising extracts from Souroubea and Platanus species, which provide anxiolytic activity beyond betulinic acid content, is used to treat anxiety and reduce cortisol levels, offering a synergistic alleviation of anxiety and fear responses, and can be administered in various forms including teas, powders, or extracts, with a ratio of Marcgraviaceae to Platanaceae ranging from 1:99 to 99:1.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional pharmaceutical preparations are used to treat anxiety and elevated glucocorticoid-related disorders, then therapeutic efficacy is achieved, but significant side effects occur
Solution Approach 1:
The patent employs plant-derived compounds (betulinic acid and related compounds) as natural, temporary alternatives to conventional pharmaceuticals. These natural compounds provide therapeutic effects without the persistent harmful side effects of synthetic medications, allowing the body to return to baseline without long-term damage.
Solution Approach 2:
The patent utilizes complex plant compositions containing multiple active compounds (betulinic acid, betulin, and other triterpenoids) working synergistically. This composite approach from natural sources provides efficacy while reducing the harmful side effects associated with single-component synthetic pharmaceuticals.
2Reliability
If existing herbal remedies are used to treat anxiety and stress, then some therapeutic effects are achieved, but the underlying physiological responses to stress and anxiety are not fully addressed
Solution Approach 1:
The patent specifically targets and modifies key physiological parameters including cortisol levels, ACTH secretion, and HPA axis activity. By changing these specific biochemical parameters, the invention addresses the underlying physiological responses to stress rather than just symptomatic relief.
Solution Approach 2:
The patent compounds act on the HPA axis feedback mechanisms, influencing cortisol production and ACTH secretion through natural feedback loops. This addresses the complete physiological stress response system rather than isolated symptoms.
Data Source
AI summary
The disclosure provides compositions containing preparations from plants of the family Marcgraviaceae and from plants of the family Platanaceae. The disclosure also provides methods and uses of plant preparations for treating anxiety, stress and glucocorticoid related disorders.