Plant Lipid Compositions Modulating Gene Expression in Keratinous Materials
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current cosmetic and pharmaceutical formulations using vegetable oils and butters lack scientific evidence of biological effects on keratinous materials, and there is a need for a technological approach to modulate gene expression for effective treatment of skin, hair, scalp, nails, and eyelashes.
Innovation Solution
Development of cosmetic and pharmaceutical compositions containing plant lipids such as acai oil, andiroba oil, buriti oil, and others, which modulate gene expression to treat keratinous materials by incorporating these lipids with cosmetically or pharmaceutically acceptable carriers, allowing for topical, oral, or parenteral administration in various forms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If vegetable oils and butters are used as emollients in cosmetic formulations, then skin moisturization is improved by reducing transepidermal water loss, but there is a lack of scientific evidence demonstrating biological effects on keratinous materials
Solution Approach 1:
The patent changes the functional parameter of plant lipids from simple emollience to gene expression modulation. By selecting specific plant lipids with particular fatty acid compositions and administering them at optimized concentrations, the formulation transforms conventional moisturizing agents into biologically active compounds that modulate gene expression in keratinous materials, thereby providing scientifically demonstrable biological effects while maintaining formulation feasibility
Solution Approach 2:
The patent introduces plant lipids as intermediary substances that mediate between topical application and gene expression modulation. These lipids serve as carriers that penetrate keratinous materials and interact with cellular mechanisms to regulate gene expression, bridging the gap between external cosmetic application and internal biological effects, thus providing scientifically verifiable mechanisms of action
2Reliability
If plant lipids are used to modulate gene expression in keratinous materials, then treatment effectiveness is improved, but the mechanism of action becomes more complex compared to conventional emollients
Solution Approach 1:
The patent extracts and isolates the specific gene-modulating activity from the complex mixture of plant lipids. By identifying and focusing on particular lipids with demonstrated gene expression modulating capabilities, the invention separates the active therapeutic mechanism from the bulk material, simplifying the understanding of the mechanism while maintaining treatment effectiveness through targeted lipid selection
Solution Approach 2:
The patent replaces the simple physical emollience mechanism with a biochemical gene expression modulation mechanism. Instead of relying solely on physical film formation and water retention, the formulation utilizes plant lipids that interact with cellular biochemical pathways to regulate gene expression, substituting a complex but more effective biological mechanism for the simpler physical mechanism of conventional emollients
Data Source
Figure 1
AI summary
The present invention is directed to cosmetic and/or pharmaceutical compositions comprising at least one plant lipid, having as its main application the treatment of keratinous materials, particularly skin, hair, scalp, nails and eyelashes, by modulating the expression of genes responsible for ROS metabolism, lipid metabolism, skin integrity, cell renewal, cell differentiation, strengthening the skin barrier, calcium metabolism, cell proliferation, tissue healing and/or repair, cell adhesion, carbohydrate metabolism, hydration, skin homeostasis/maintenance, skin defense and/or protection, remodeling and/or extracellular matrix synthesis, skin peeling, tissue maintenance, cell signaling, normal development of the epidermis, epidermal barrier function, development of the skin, dermis-epidermis junction, antiinflammatory or antioxidant action in keratinous materials, through the modulation of the expression of the genes involved in said functions. The present invention also teaches methods of modulating the expression of genes responsible for such functions of keratinous materials and the use of said plant lipids in the preparation of said compositions.