Lactobacillus Plantarum Composition for Gut-Brain Axis Modulation
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Solution Overview
Problem
Current treatments for mental illnesses and symptoms affecting mental health, such as depression, anxiety, and cognitive decline, often have negative side effects and do not effectively address the underlying gut-brain axis influence, while chronic stress can lead to severe health conditions and gastrointestinal disorders.
Innovation Solution
Compositions comprising novel Lactobacillus plantarum strains, including LP12151, LP12418, and LP12407, are used to prevent and treat mental illnesses and stress-related conditions by promoting positive mental and cognitive health through gut microbiota modulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for mental illnesses are used, then symptoms may be temporarily relieved, but negative side effects occur and underlying gut-brain axis influence is not addressed
Solution Approach 1:
The patent introduces probiotics (Lactobacillus plantarum strains) as an intermediary substance that acts on the gut microbiota to modulate the gut-brain axis. Instead of directly treating mental illness symptoms with conventional medications that cause side effects, the probiotics serve as a mediator that indirectly influences brain function through gut microbiota modulation, thereby relieving symptoms without the harmful side effects of traditional psychotropic drugs
Solution Approach 2:
The patent extracts and addresses the root cause of mental illness by focusing on the gut-brain axis connection. Rather than treating symptoms superficially, the invention extracts the underlying mechanism (gut microbiota influence on brain function) and targets it specifically with probiotic therapy, thereby treating the root cause while avoiding the side effects of symptom-only management
2Ease of operation
If conventional treatments address symptoms directly, then temporary relief is achieved, but the underlying gut-brain axis influence remains unaddressed
Solution Approach 1:
The patent applies preliminary action by first modulating the gut microbiota with probiotics before addressing mental health outcomes. This preliminary step of restoring gut flora balance creates a foundation for improved brain function, preventing the need for more complex interventions later and providing comprehensive treatment that addresses the root cause before symptoms manifest
3Productivity
If chronic stress is not addressed, then daily life continues, but severe health conditions and gastrointestinal disorders develop
Solution Approach 1:
The patent applies preliminary anti-action by using probiotics to counteract the harmful effects of chronic stress on the gut-brain axis before severe health conditions develop. The probiotics preemptively protect against stress-induced gut microbiota dysbiosis and subsequent neurological damage, allowing individuals to maintain daily functioning while preventing the development of severe stress-related disorders
Data Source
AI summary
The invention relates to compositions comprising Lactobacillus plantarum, and methods and uses of said compositions for preventing and/or treating mental illness, symptoms affecting mental health and/or conditions associated with chronic stress, in a mammal. The invention can be applied in restoring, maintaining, and/or promoting mental (including cognitive) health and has potential applications, inter alia, in the area of dietary and food supplements, medicaments and pharmaceuticals.