Plasma and Antigen-Specific Immunoglobulin Combination for Allergy Treatment
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Solution Overview
Problem
Current allergen immunotherapy for allergic diseases is burdensome, requiring frequent injections over several years, and there is a need for more effective pharmaceutical compositions and methods for prevention or treatment.
Innovation Solution
A combination of pooled plasma immunoglobulin and antigen-specific polyclonal immunoglobulin, such as intramuscular immunoglobulin with polyclonal anti-Tetanus toxoid, anti-Rabies, or anti-Varicella immunoglobulin, administered intramuscularly or intravenously, to modulate the immune system and reduce allergic responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional allergen immunotherapy is used, then allergic disease can be treated, but the treatment requires frequent injections over several years making it quite onerous
Solution Approach 1:
The patent combines plasma immunoglobulin (providing broad immune modulation) with antigen-specific immunoglobulin (providing targeted allergen tolerance) into a single pharmaceutical composition. This merging of two therapeutic mechanisms into one treatment allows for reduced injection frequency while maintaining effectiveness, directly addressing the contradiction between treatment reliability and ease of operation
2Reliability
If plasma immunoglobulin and antigen-specific immunoglobulin are combined, then allergic disease treatment effectiveness is improved, but the pharmaceutical composition complexity increases
Solution Approach 1:
The patent merges plasma immunoglobulin and antigen-specific immunoglobulin into a single integrated pharmaceutical composition rather than requiring separate administrations. This combination approach improves treatment effectiveness while managing composition complexity through unified formulation rather than multiple separate treatments
Solution Approach 2:
The combined pharmaceutical composition serves multiple functions simultaneously: plasma immunoglobulin provides broad immune system modulation while antigen-specific immunoglobulin provides targeted tolerance to specific allergens. This multi-functionality in a single composition addresses both general immune dysregulation and specific allergen sensitivity, improving overall treatment effectiveness without requiring multiple separate compositions
Data Source
AI summary
A method of use of plasma immunoglobulin, such as intramuscular immunoglobulin, in combination with polyclonal antigen-specific immunoglobulin in the treatment or prevention of allergic disease is provided. Also provided is a pharmaceutical composition including plasma immunoglobulin in combination with polyclonal antigen-specific immunoglobulin.