Plasma Collection Optical Detection for Pure Volume Control
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Solution Overview
Problem
Existing plasma collection systems fail to accurately determine the volume of pure plasma collected, leading to overcollection from donors due to the inability to differentiate between plasma and anticoagulant, thus violating regulatory volume limits.
Innovation Solution
A method and system that calculates the percentage of anticoagulant in the collected plasma based on donor hematocrit and system parameters, allowing precise determination of pure plasma volume by monitoring anticoagulant introduction and separation, and using sensors to adjust the collection process accordingly.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If plasma collection is based on total collection volume without differentiating plasma from anticoagulant, then the collection process is simple to operate, but the measurement precision of pure plasma volume is insufficient leading to overcollection
Solution Approach 1:
The patent replaces mechanical/manual volume measurement with optical detection. A detector (optical sensor) monitors the plasma/anticoagulant mixture in the collection bag by detecting light transmission or reflection properties, automatically calculating pure plasma volume based on refractive index or optical density differences, thereby achieving precise measurement without complex manual procedures
Solution Approach 2:
The patent introduces an intermediary detection mechanism (optical sensor/detector) that indirectly measures pure plasma volume by detecting physical property differences between plasma and anticoagulant in the mixture, rather than attempting direct volume measurement or separation
2Productivity
If plasma collection follows fixed volume limits without individual donor assessment, then the collection process is efficient and quick, but the reliability of adhering to regulatory limits is compromised
Solution Approach 1:
The patent implements a feedback control system where the optical detector continuously monitors the collected plasma/anticoagulant mixture, calculates real-time pure plasma volume, and provides feedback to the control system. The system automatically adjusts or stops collection when the calculated pure plasma volume reaches the regulatory limit (e.g., 800 mL), ensuring reliable compliance while maintaining efficient continuous operation
Solution Approach 2:
This principle is not applicable to this patent as the solution does not involve chemical oxidation or acceleration through strong oxidants
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate collection of a target volume of pure plasma, adhering to regulatory limits and optimizing plasma yield by accounting for individual donor characteristics.
Implementation Method 1
separate, using the blood component separation device, the withdrawn whole blood into a plasma component and at least a second blood component
Data Source
AI summary
A method for collecting plasma includes determining the weight and hematocrit of a donor, and inserting a venous-access device into the donor. The method then withdraws blood from the donor through a draw line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate (1) a percentage of anticoagulant in the collected plasma component, and (2) a volume of pure plasma collected within the plasma collection container. The volume of pure plasma may be based, at least in part, on the calculated percentage of anticoagulant. The method may continue until a target volume of pure plasma is collected within the plasma collection container.