Plasma Concentration Feedback for Radiation Dose Timing
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Solution Overview
Problem
Current radiation oncology systems, such as boron neutron capture therapy (BNCT) systems, inaccurately estimate the dose rate due to not considering the patient's drug concentration in plasma, leading to potential underestimation or overestimation of the delivered dose.
Innovation Solution
A dose control system that calculates the corrected dose rate distribution based on real-time drug concentration in plasma using correction coefficients, and adjusts the irradiation time accordingly to ensure accurate dose delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If the dose rate is estimated without considering real drug concentration in plasma, then the calculation process is simple, but the dose delivery accuracy deteriorates
Solution Approach 1:
The system implements feedback by measuring the real drug concentration in plasma and using it to correct the dose rate calculation. The correction coefficient is determined based on the measured drug concentration, creating a closed-loop system that continuously adjusts the dose rate to match actual patient conditions, thereby resolving the contradiction between simple calculation and accurate dose delivery.
Solution Approach 2:
The system changes the parameter used for dose rate calculation from a fixed theoretical drug concentration to a variable real drug concentration measured from the patient. By introducing a correction coefficient that varies with actual drug concentration levels, the system adapts the calculation to reflect real physiological conditions, improving dose accuracy without requiring completely new calculation methodologies.
2Ease of operation
If the theoretical drug concentration is used for dose rate estimation, then the system operation is simple, but the reliability of dose delivery deteriorates
Solution Approach 1:
The system introduces a correction coefficient as an intermediary element between the theoretical dose rate calculation and the actual dose delivery. This correction coefficient is determined based on real drug concentration measurements and serves as a bridge that adjusts the theoretical values to reflect actual patient conditions, thereby improving reliability while maintaining the simplicity of the underlying calculation framework.
3Difficulty of detecting and measuring
If the dose rate is calculated without real-time drug concentration data, then the measurement process is simple, but the precision of dose rate estimation deteriorates
Solution Approach 1:
The system employs feedback by continuously measuring real drug concentration in plasma and using this information to correct the dose rate estimation. The measured drug concentration feeds back into the calculation process through the correction coefficient, creating a self-adjusting system that improves dose rate precision while keeping the measurement process relatively simple through the use of established correction relationships.
Data Source
AI summary
A dose control system, including a processing device configured to obtain the real drug concentration in plasma of a patient. The processing device is further configured to calculate the corrected dose rate distribution datum based on the real drug concentration in plasma and a set of correction coefficients. The processing device is further configured to calculate the irradiation time based on the corrected dose rate distribution datum and the prescribed dose distribution datum. The processing device is further configured to control the irradiation device to irradiate the patient for the irradiation time.