Low-Capacity Plasma Exchange Device Centrifugal Separation

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Solution Overview

Problem

Existing medical treatment methods, such as oral medication and intravenous infusion, often result in poor treatment effects for patients requiring long-term and regular clinical interventions.

Innovation Solution

A low-capacity plasma exchange device with a centrifuge component, medication pump, anticoagulant pump, blood drawing pump, and display screen, which separates plasma from blood cells, adds treatment medication, and reinfuses them into the patient, stimulating the hematopoietic system and organs.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If oral medication and intravenous infusion are used for long-term treatment, then the treatment process is simple and easy to administer, but the treatment effect is poor and cannot effectively improve the patient's condition

Engineering Contradiction:
Improveease of administrationVSAvoidtreatment effect
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The patent extracts plasma from the patient's blood through centrifugal separation, removing the problematic plasma component that contains harmful substances and antibodies. This extracted plasma is then discarded while the blood cells are reinfused, achieving a treatment effect that oral medication and simple infusion cannot provide.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent introduces an intermediary substance (albumin or other plasma substitutes) to replace the removed plasma. This intermediary maintains blood volume and osmotic pressure while avoiding the harmful effects of the patient's own plasma, thereby improving treatment efficacy for conditions like nephrotic syndrome and allergic diseases.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If plasma exchange is performed to improve treatment effect, then the treatment efficacy is significantly improved, but the device complexity and operational complexity increase

Engineering Contradiction:
Improvetreatment effectVSAvoiddevice structure
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The plasma exchange device integrates multiple functions into a single system: blood drawing, centrifugal separation, plasma extraction, medication mixing, and reinfusion. This multi-functional design consolidates what would otherwise require multiple separate devices, making the complex plasma exchange procedure accessible in clinical settings without requiring an array of separate equipment.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The device employs a nested structure where the centrifuge tube is placed within the plasma separator, which is itself integrated into the larger exchange device. The medication mixing chamber is nested within the reinfusion system. This nesting approach compactly organizes complex components, reducing overall device footprint and operational complexity while maintaining full plasma exchange functionality.

Inventive Principle:
Principle #7Nested doll (Nesting)

3Reliability

If plasma exchange is performed to improve treatment effect, then the treatment outcome is enhanced, but the time required for the procedure increases

Engineering Contradiction:
Improvetreatment effectVSAvoidtreatment time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The plasma exchange procedure is designed as a continuous process where blood is drawn, separated, plasma is removed and discarded, blood cells are collected, medication is mixed in, and the mixture is reinfused without significant interruption. This continuous operation eliminates the need for separate steps and waiting periods, reducing total treatment time while maintaining the therapeutic benefits of plasma exchange.

Inventive Principle:
Principle #20Continuity of useful action

Solution Approach 2:

The device performs preliminary separation of plasma from blood cells before the actual exchange process begins. The centrifugal separation prepares the blood components in advance, allowing the subsequent plasma removal and reinfusion to proceed efficiently. This preliminary action prevents delays that would occur if separation had to be performed during the exchange process itself.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Significantly improves treatment efficacy by effectively exchanging plasma and blood cells, enhancing the patient's condition and treatment outcomes compared to traditional methods.

Implementation Method 1

a centrifuge component arranged inside the chassis assembly

Methodology Applied
Scientific EffectCentrifugal separation: Centrifugal Separation

Data Source

PatentUS20240374803A1Low-capacity plasma exchange device
Publication Date: 2024.11.14 SCINOMED
  • US20240374803A1 patent drawing
  • US20240374803A1 patent drawing
  • US20240374803A1 patent drawing

AI summary

The disclosure describes a low-capacity plasma exchange device, comprising a chassis assembly, wherein a centrifuge component is arranged on the inner side of the chassis assembly, and a medication pump, an anticoagulant pump, and a blood drawing pump are arranged on one side of the top of the chassis assembly relative to the centrifuge component, and a first air detector component is arranged on one side of both the medication pump and the blood drawing pump; in the disclosure, the low-capacity plasma exchange device first collects a certain amount of plasma from the patient's body, then mixes the treatment medication into the blood cells after the removal of plasma and reinfuses them back into the patient's body, achieving the effect of exchange treatment, significantly improving the treatment effect, and solving the problem of poor treatment effects of oral medication and infusion therapy in the existing technology.