Plasma Glucose Estimation From Whole Blood Sensor Response
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Solution Overview
Problem
Existing methods for measuring glucose concentration in blood plasma using whole blood samples face discrepancies due to hematocrit values, especially at high glucose concentrations, leading to inaccuracies.
Innovation Solution
A method and apparatus that utilize electrochemical sensors to measure whole blood glucose concentration, calculate a correction value based on hematocrit and sensor response, and apply formulas to correct for discrepancies, enabling accurate plasma glucose concentration determination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If glucose concentration is measured using whole blood sample with conventional correction formula, then measurement process is simplified, but measurement precision deteriorates due to hematocrit value discrepancies
Solution Approach 1:
The patent introduces a response index as a new parameter to characterize sensor performance variations. By incorporating this parameter into the correction formula along with hematocrit value, the system dynamically adjusts the correction based on actual sensor response, thereby maintaining measurement precision across different hematocrit conditions while preserving the simplicity of whole blood measurement.
2Device complexity
If conventional correction formula is used, then device complexity is reduced, but measurement precision deteriorates at high glucose concentrations
Solution Approach 1:
The patent modifies the correction approach by introducing the response index parameter that captures sensor behavior at different glucose concentrations. The corrected formula incorporates this parameter to compensate for non-linear sensor responses at high glucose levels, thereby extending the accurate measurement range without significantly increasing device complexity.
3Ease of operation
If simple correction based on hematocrit is applied, then ease of operation is maintained, but reliability deteriorates due to sensor response variations
Solution Approach 1:
The patent introduces the response index as an additional correction parameter that accounts for sensor-to-sensor variations and environmental effects. By incorporating this parameter into the correction formula, the system achieves more reliable and consistent measurements across different sensors and conditions while maintaining operational simplicity through automated calculation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate measurement of plasma glucose concentration from whole blood samples, independent of hematocrit values, by correcting for sensor response and hematocrit effects using specific formulas.
Implementation Method 1
measuring a whole blood component concentration using a whole blood sample, using an electrochemical sensor method
Data Source
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AI summary
Provided is a method for reducing the discrepancy between a measured value of component concentration in whole blood and a measured value of component concentration in plasma. An aspect of the invention relates to a method for measuring a plasma component concentration using a whole blood sample. The method includes: measuring a whole blood component concentration using a whole blood sample, using an electrochemical sensor method; computing a correction value using a whole blood component concentration measured value obtained through the measurement, a hematocrit value of the whole blood sample, and a response index of a sensor used for the measurement of the whole blood component concentration; and computing a plasma component concentration using the correction value and the whole blood component concentration measured value.