Non-thermal Plasma Keloid Treatment Device
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Solution Overview
Problem
Current technologies lack effective methods for preventing and treating keloids, which are characterized by abnormal collagen deposition and proliferation, causing cosmetic and functional issues, with no existing plasma-based treatments available.
Innovation Solution
A non-thermal atmospheric-pressure plasma treatment device is developed, utilizing argon and nitrogen gases, and a pharmaceutical composition including an expression inhibitor of EGFR or STAT3 gene to inhibit collagen deposition and fibroblast mobility, thereby preventing and treating keloids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional plasma treatment technologies are applied to skin, then skin surface modification is achieved, but no effective treatment for keloid fibroblasts and collagen deposition is obtained
Solution Approach 1:
The patent applies non-thermal atmospheric-pressure plasma with specific parameters (power 10 to 50 kHz, power peak 0.1 to 10 kV) to achieve selective inhibition of keloid fibroblast activity while maintaining normal skin cell function. This parameter optimization resolves the contradiction by making plasma treatment effective for keloids without requiring fundamental changes to plasma generation technology.
2Reliability
If plasma treatment is used to inhibit collagen deposition, then keloid fibroblast activity is reduced, but device complexity increases
Solution Approach 1:
The plasma generation apparatus is designed with multi-functionality, capable of treating both normal skin and keloid tissues using the same device platform. The system includes a power supply, plasma generator, gas supply path, and housing that can deliver non-thermal plasma for various dermatological applications, reducing the need for separate specialized devices for different skin conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively inhibits collagen deposition and mobility in keloid fibroblasts, offering a promising solution for keloid prevention and treatment, as demonstrated by reduced cell migration and collagen synthesis in treated cells.
Implementation Method 1
non-thermal atmospheric-pressure plasma keloid treatment device
Data Source
AI summary
The present invention relates to a non-thermal atmospheric-pressure plasma keloid treatment device and a use thereof. The non-thermal atmospheric-pressure plasma keloid treatment device according to the present invention has effects of inhibiting collagen deposition in keloid fibroblasts and mobility thereof, and thus, is expected to be greatly useful for preventing and treating keloids.