Plasma Purifying Device Air Pump Pressure Control

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Solution Overview

Problem

Current plasma purifying devices face challenges in efficiently and safely recovering blood and plasma without risk of coagulation, requiring complex operations and often necessitating the involvement of two personnel due to the need to manage flow rates and prevent clogging in plasma separators and adsorbers.

Innovation Solution

The integration of an air pump into the plasma purifying device, controlled by a unit that adjusts flow rates to maintain a higher pressure in the filtration side space than the blood side space, allowing continuous operation of the blood pump and controlled delivery of plasma to the blood side space or plasma circuit, utilizing the properties of hollow fiber filtration membranes to prevent air passage and facilitate plasma recovery without stopping the blood pump.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of substance

If the blood pump is stopped to recover plasma in the filtration side space, then plasma can be recovered, but blood coagulation risk increases and operation complexity increases

Engineering Contradiction:
Improveplasma recoveryVSAvoidblood coagulation risk
Core Design Contradiction:
Loss of substanceVSReliability

Solution Approach 1:

The blood pump continues to operate continuously during plasma recovery without stopping, maintaining blood circulation in the collected blood circuit and return blood circuit. This eliminates the need to stop the blood pump for plasma recovery, thereby reducing blood coagulation risk and operational complexity while still enabling complete plasma recovery from the filtration side space

Inventive Principle:
Principle #20Continuity of useful action

Solution Approach 2:

An air pump is introduced as an intermediary device to supply air to the filtration side space of the plasma separator. This air supply creates positive pressure that drives plasma out of the filtration side space into the plasma circuit, enabling plasma recovery without stopping the blood pump or requiring complex manual operations

Inventive Principle:
Principle #24Intermediary (Mediator)

2Loss of substance

If the blood pump is stopped to disconnect collected blood circuit from patient, then plasma recovery can proceed, but operation time increases and productivity decreases

Engineering Contradiction:
Improveplasma recovery completenessVSAvoidplasma recovery efficiency
Core Design Contradiction:
Loss of substanceVSProductivity

Solution Approach 1:

The blood pump operates continuously throughout the entire plasma recovery process without interruption. The collected blood circuit remains connected to the patient throughout, eliminating the need for disconnection and reconnection operations. This continuous operation significantly reduces plasma recovery time and improves productivity while ensuring complete plasma recovery

Inventive Principle:
Principle #20Continuity of useful action

Solution Approach 2:

The air pump serves as a mediator that enables plasma recovery while the blood pump continues to circulate blood. By supplying air to the filtration side space, the air pump creates the necessary pressure differential to drive plasma into the plasma circuit without requiring the blood pump to stop or the collected blood circuit to be disconnected from the patient

Inventive Principle:
Principle #24Intermediary (Mediator)

3Reliability

If manual operation with two personnel is used to manage flow rates and prevent clogging, then plasma separator reliability is maintained, but device complexity and operation difficulty increase

Engineering Contradiction:
Improveplasma separator functionVSAvoidoperation complexity
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The system automatically manages plasma recovery by utilizing the continuous blood circulation to maintain appropriate flow rates through the plasma separator. The air pump automatically supplies air to the filtration side space, creating positive pressure that drives plasma recovery without requiring manual intervention to adjust flow rates or prevent clogging. This self-service mechanism maintains plasma separator reliability while significantly reducing operational complexity

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The air pump acts as an automated intermediary that manages the plasma recovery process. By controlling air supply to the filtration side space, it automatically regulates the pressure differential across the plasma separator, ensuring optimal flow rates and preventing clogging without requiring manual operation by two personnel

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method enables continuous plasma recovery without coagulation risks, reduces the need for two-person operations, and significantly improves the efficiency of plasma recovery by allowing blood and plasma to be recovered without disconnecting the collected blood circuit from the patient.

Implementation Method 1

controlling flow rates of the air pump and the plasma pump so that the pressure of the filtration side space of the plasma separator is higher than the pressure of the blood side space while delivering blood to the blood side space of the plasma separator by continuing to operate the blood pump without stopping following completion of plasma purification, and then delivering plasma remaining in the filtration side space of the plasma separator to the blood side space of the plasma separator or to the plasma circuit by supplying air from the air pump

Methodology Applied
Scientific EffectPressure gradient: Pressure Gradient

Implementation Method 2

utilizing the properties of hollow fiber filtration membranes to prevent air passage and facilitate plasma recovery without stopping the blood pump

Methodology Applied
Scientific EffectHydrophobic membrane filtration: Semipermeable Membrane

Data Source

PatentEP2351588B1Plasma purifying device
Publication Date: 2016.01.27 ASAHI KASEI MEDICAL CO LTD
  • EP2351588B1 patent drawingFigure 1
  • EP2351588B1 patent drawingFigure 2
  • EP2351588B1 patent drawingFigure 3

AI summary

A plasma purifying device is provided that is capable of recovering blood and plasma remaining within the plasma purifying device easily and without risk of coagulation, following completion of plasma purification therapy. The plasma purifying device has a control unit controls flow rates of the air pump and a plasma pump so that a pressure of the filtration side space of the plasma separator is higher than a pressure of the blood side space while delivering blood to the blood side space of the plasma separator by continuing to operate a blood pump without stopping following completion of plasma purification and then delivers plasma remaining in a filtration side space of a plasma separator to a blood side space of the plasma separator or to a plasma circuit by supplying air from an air pump.