Plasma Radical Solution pH Stabilization for Peroxynitrite
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Solution Overview
Problem
Existing plasma radical solutions face challenges in maintaining sterilization and antibacterial effects due to instability of radicals, particularly peroxynitrite, which is difficult to synthesize and loses properties quickly when dissolved in solution.
Innovation Solution
A plasma radical solution is developed that generates and maintains peroxynitrite by adjusting pH and NO3- concentration using NaH2PO4, ensuring stability and effectiveness against bacteria, fungi, and viruses, with a solvent of distilled or purified water, and storage at 85° C or less.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If peroxynitrite is generated by dissolving plasma radicals in solution, then sterilization and antibacterial effects are achieved, but the radicals become unstable and lose their properties quickly
Solution Approach 1:
The patent applies preliminary action by adjusting the pH to weakly acidic conditions (pH 5-6) and adding phosphate buffer (NaH2PO4) before the radicals fully decompose. This pre-adjustment creates a stable environment that preserves peroxynitrite and other reactive species, extending their effective lifetime in solution while maintaining sterilization capability.
Solution Approach 2:
The patent changes the pH parameter to weakly acidic conditions (pH 5-6) and controls the concentration of phosphate buffer to stabilize the radicals. By adjusting these parameters, the solution maintains peroxynitrite stability without sacrificing the sterilization effectiveness that requires certain levels of reactive oxygen and nitrogen species.
2Stability of the object's composition
If the pH and NO3- concentration are adjusted to maintain sterilization effects, then the solution stability improves, but the solution composition becomes more complex
Solution Approach 1:
The patent uses phosphate buffer (NaH2PO4) as an intermediary substance that mediates between the unstable radicals and the solution environment. The buffer captures excess protons and stabilizes the pH, indirectly protecting the peroxynitrite from decomposition while adding only a single, well-characterized chemical component to the solution.
3Ease of manufacture
If peroxynitrite is synthesized naturally in solution, then the solution can be prepared simply, but peroxynitrite is difficult to synthesize and maintain
Solution Approach 1:
The patent performs preliminary pH adjustment and phosphate buffer addition before the radicals fully decompose, creating optimal conditions for peroxynitrite stabilization. This pre-preparation step is simple to execute and ensures that when peroxynitrite forms from plasma radical dissolution, it remains stable in solution rather than rapidly decomposing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution maintains sterilization and antibacterial effects for an extended period, effectively treating skin wounds, acne, atopy, psoriasis, and viral skin diseases, while being non-toxic and safe for human use.
Implementation Method 1
Plasma is called a fourth material state, and refers to a state in which negatively charged electrons, positively charged ions and neutral particles (molecules and atoms) are mixed
Implementation Method 2
negatively charged electrons, positively charged ions and neutral particles (molecules and atoms) are mixed
Implementation Method 3
neutral particles collide with molecules to generate chemically active species, and the ions create conditions in which chemical reactions may occur on the surface of an object to be treated
Implementation Method 4
peroxynitrite is generated in the solution by unstable radicals generated by plasma
Data Source
AI summary
The present invention relates to a plasma radical solution and a method for preparing the same, and more particularly, to a plasma radical solution and a method for preparing the same capable of being used in various bio-fields such as sterilization, antibacterial, wound healing, acne relief, atopy treatment, psoriasis treatment, dermatitis treatment, viral skin disease treatment, skin soothing and muscle regeneration by preparing a plasma radical solution containing radicals generated through plasma.