Plasma-Treated Surfaces for Stable Lyophilized Pellet Adhesion
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Solution Overview
Problem
Solid compositions do not adhere strongly to surfaces, leading to dislocation or loosening during shipment or handling, which can complicate or prevent reconstitution and adversely affect assay performance.
Innovation Solution
Plasma treatment of surfaces to enhance adhesion by increasing surface energy and wettability, allowing solid compositions to be adhered to the treated surfaces, such as plastic, and forming a lyophilized pellet that remains attached during processes like shipping and handling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If solid compositions are formed by drying a liquid solution on a conventional surface, then the composition can be stored in a stable solid state, but the composition becomes dislocated or loose during shipment or handling
Solution Approach 1:
The surface is plasma-treated before the liquid solution is applied and dried. This preliminary treatment modifies the surface properties to enhance adhesion, ensuring that when the solid composition forms during drying, it strongly adheres to the surface and remains in place during subsequent handling and shipping.
2Reliability
If plasma treatment is applied to increase surface hydrophilicity and wettability, then adhesion of solid compositions is significantly improved, but the surface treatment process complexity increases
Solution Approach 1:
The patent replaces mechanical adhesion methods with plasma treatment, which uses electromagnetic energy to modify surface properties. This substitution achieves superior adhesion through chemical and physical changes at the molecular level rather than relying on mechanical interlocking or simple surface contact.
3Reliability
If the surface is treated to increase hydrophilicity, then the interaction of the reagent with the surface is strengthened, but the treatment requires additional processing steps and energy
Solution Approach 1:
The patent changes the surface energy parameters through plasma treatment, increasing hydrophilicity and wettability. By adjusting plasma treatment parameters such as power, gas flow rate, and treatment duration, optimal adhesion is achieved while managing energy consumption efficiently.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Plasma-treated surfaces improve the adhesion of solid compositions, ensuring they remain attached during agitation, thereby facilitating complete reconstitution and maintaining assay performance.
Implementation Method 1
plasma treatment of a surface can improve the adhesion to the surface of solid compositions formed by drying a liquid solution
Implementation Method 2
using corona discharge to treat surfaces before forming lyophilized pellets
Implementation Method 3
drying a solution on the plasma-treated surface and forming a solid composition from the solution
Implementation Method 4
forming lyophilized pellets
Data Source
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AI summary
The disclosure provides solid compositions such as lyophilisates adhered to surfaces such as plasma-treated surfaces and related methods, uses, kits, intermediates, starting materials, and downstream products.