Cold Atmospheric Plasma Wart Treatment

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Solution Overview

Problem

Current treatments for skin warts, such as over-the-counter products and liquid nitrogen, often fail to provide effective and long-lasting solutions, leading to recurrence and frustration for both patients and dermatologists.

Innovation Solution

The use of non-thermal, atmospheric pressure plasma is employed to treat warts by guiding it over the affected areas, utilizing a device with a high-voltage electrode, insulating barrier, and power source to generate non-thermal plasma without causing thermal damage to the tissue.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional treatments such as liquid nitrogen or over-the-counter products are used to treat warts, then the treatment process is simple and accessible, but the effectiveness is poor and recurrence is common

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidtreatment device complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces conventional mechanical or chemical wart removal methods (such as liquid nitrogen freezing or topical salicylic acid applications) with a plasma-based treatment system. The plasma device uses controlled electrical discharge to generate reactive species that selectively destroy wart tissue, thereby improving treatment effectiveness and reducing recurrence while maintaining practical usability through a handheld applicator design.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Duration of action of moving object

If aggressive treatments are applied to remove warts quickly, then the treatment duration is reduced, but the risk of tissue damage and scarring increases

Engineering Contradiction:
Improvetreatment durationVSAvoidtissue damage risk
Core Design Contradiction:
Duration of action of moving objectVSObject-affected harmful factors

Solution Approach 1:

The patent employs precise control of plasma generation parameters including voltage, current, gas flow rate, and treatment duration. By optimizing these parameters, the system achieves effective wart removal within seconds to minutes while maintaining tissue temperature and energy levels that prevent damage to surrounding healthy skin, thereby eliminating the trade-off between treatment speed and safety.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent introduces a controlled plasma field as an intermediary between the energy source and the wart tissue. This plasma mediator delivers therapeutic effects through reactive oxygen and nitrogen species that selectively target abnormal cells, while the system's control mechanisms ensure that energy delivery remains within safe thresholds, preventing thermal or electrical damage to surrounding tissues.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Object-affected harmful factors

If multiple treatment sessions are scheduled to ensure complete wart removal, then the risk of tissue damage is reduced, but the treatment time and patient burden increase

Engineering Contradiction:
Improvetissue damage riskVSAvoidtotal treatment time
Core Design Contradiction:
Object-affected harmful factorsVSLoss of time

Solution Approach 1:

The patent achieves complete wart removal in a single continuous treatment session by maintaining optimal plasma discharge conditions throughout the procedure. The system continuously delivers controlled plasma energy across the entire wart surface, ensuring thorough destruction of all abnormal tissue without interruption, thereby eliminating the need for multiple follow-up appointments while maintaining safety through real-time parameter monitoring.

Inventive Principle:
Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method achieves partial to complete amelioration of warts with minimal risk of tissue damage, as demonstrated by clinical trials where all lesions of one patient resolved and a new wart cleared with subsequent treatments, although recurrence was noted in another patient.

Implementation Method 1

a high voltage electrode, an insulating or semiconducting barrier, a power source capable of providing a voltage, and a pulse generator. The device is capable of generating non thermal plasma

Methodology Applied
Scientific EffectPlasma generation: Plasma

Implementation Method 2

guiding non-thermal, atmospheric pressure plasma over areas of the tissue having the wart

Methodology Applied
Scientific EffectIonization: Ionisation

Implementation Method 3

a power source capable of providing a voltage, and a pulse generator. The device is capable of generating non thermal plasma

Methodology Applied
Scientific EffectPulsed electrical discharge: Electrical Discharge Machining

Data Source

PatentUS12329982B2Use of cold atmospheric pressure plasma to treat warts
Publication Date: 2025.06.17 DREXEL UNIV
  • US12329982B2 patent drawing
  • US12329982B2 patent drawing

AI summary

A method for treating a wart on skin of a patient includes guiding non-thermal, atmospheric pressure plasma over areas of the tissue having the wart for a length of time effective to give rise to an at least partial amelioration of the wart.