Non-Thermal Plasma Wound Coating Device

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Solution Overview

Problem

Existing plasma-based methods for depositing polymer coatings require precursor materials that react within the plasma, limiting the degree of polymerization and potentially damaging active agents, which restricts the effectiveness of the coating process.

Innovation Solution

A non-thermal plasma device is used to apply a bioresorbable coating to wounds, incorporating active compounds like proteins, biopolymers, or synthetic polymers, which are introduced as aerosols and interact with the plasma to form a coating that aids in wound healing, allowing for greater control over the polymerization process and preserving sensitive materials.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If plasma is used to induce polymerization of monomer to produce thin film coating, then coating deposition is achieved, but the degree of polymerization is limited and active agents may be damaged

Engineering Contradiction:
Improvecoating deposition qualityVSAvoidactive agent functionality
Core Design Contradiction:
Manufacturing precisionVSReliability

Solution Approach 1:

The patent applies preliminary action by pre-polymerizing monomers into oligomers or low molecular weight polymers before plasma treatment. This pre-prepared polymer material is then introduced to the substrate, allowing the plasma process to focus on deposition and crosslinking rather than initiating polymerization from monomers. This approach achieves complete polymerization while preserving active agents, as the polymerization occurs before exposure to plasma conditions that could damage sensitive functional groups.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent utilizes parameter changes by controlling plasma conditions (power, gas composition, pressure, exposure time) to optimize the deposition process. By adjusting these parameters, the plasma can effectively deposit and crosslink pre-formed polymers without causing excessive heating or degradation of active agents. The plasma parameters are tuned to achieve sufficient crosslinking for coating integrity while maintaining the functionality of incorporated active agents.

Inventive Principle:
Principle #35Parameter changes

2Productivity

If plasma power is increased to improve coating deposition rate, then productivity increases, but temperature-sensitive materials may be damaged

Engineering Contradiction:
Improvecoating deposition rateVSAvoidthermal damage to sensitive materials
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent exploits phase transitions by utilizing the plasma state of matter, which allows energy delivery without significant thermal heating of the substrate. The plasma phase enables reactive species to deposit polymer material at controlled rates while the substrate remains at or near ambient temperature. This phase-specific approach allows high deposition rates without thermal damage to temperature-sensitive substrates or active agents.

Inventive Principle:
Principle #36Phase transitions

Solution Approach 2:

The patent applies periodic action through pulsed plasma treatment, where plasma is applied in controlled intervals rather than continuously. This pulsed approach allows for coating deposition while providing cooling periods that prevent thermal accumulation and damage to sensitive materials. The periodic plasma application maintains productivity by delivering material in controlled bursts while protecting temperature-sensitive components.

Inventive Principle:
Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The non-thermal plasma device effectively sterilizes, coagulates, and seals wounds with a bioresorbable coating that enhances healing by maintaining the functionality of active compounds, providing a controlled and efficient deposition process that is gentle on temperature-sensitive materials.

Implementation Method 1

The use of plasma devices to promote wound healing has also been disclosed in US2008/0237484 and in WO2009/101143

Methodology Applied
Scientific EffectPlasma sterilization: Plasma

Implementation Method 2

The use of plasma devices to promote wound healing has also been disclosed in US2008/0237484 and in WO2009/101143

Methodology Applied
Scientific EffectPlasma coagulation: Coagulation

Implementation Method 3

U.S. Pat. No. 4,929,319 describes a method for depositing a polymer coating in which an aerosol is introduced into a corona plasma and the reactive species thereby generated are allowed to deposit in a substrate that is also brought into the corona plasma

Methodology Applied
Scientific EffectPlasma deposition: Deposition (physical)

Implementation Method 4

These prior documents rely on the plasma to induce the polymerisation of a monomer to produce the thin film or coating. The polymerisation can be driven through free radical (A. Bogaerts et al., Spectrochimica Acta Part B, 57 (2002) 609-658) or cationic reaction mechanisms

Methodology Applied
Scientific EffectPlasma-induced polymerization: Photopolymerisation

Data Source

PatentUS10946118B2Wound healing device
Publication Date: 2021.03.16 THERADEP TECHNOLOGIES INC
  • US10946118B2 patent drawing

AI summary

A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface.