Plasmalogen Production via Concentration and Refrigerated Standing

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Solution Overview

Problem

Existing methods for producing plasmalogen on an industrial scale result in significant reduction of obtainable plasmalogen when the alcohol extract of plasmalogen-containing animal tissue is allowed to stand at normal temperature.

Innovation Solution

Concentrating an alcohol extract of plasmalogen-containing animal tissue and then diluting the concentrate, followed by allowing it to stand under refrigeration at 2 to 15°C for 1 to 7 days, rather than at normal temperature.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of time

If the alcohol extract of plasmalogen-containing animal tissue is allowed to stand at normal temperature, then the production process is simple and fast, but the amount of obtainable plasmalogen is significantly reduced

Engineering Contradiction:

Improvestanding timeVSAvoidplasmalogen content

Core Design Contradiction:

Loss of timeVSLoss of substance

Solution Approach 1:

The patent changes the temperature parameter from normal temperature to refrigeration temperature (2 to 15°C) during the standing period. This parameter change prevents the significant reduction of plasmalogen content while maintaining the extraction process efficiency, thereby resolving the contradiction between processing time and substance loss.

Inventive Principle:

Principle #35Parameter changes

2Ease of operation

If the alcohol extract is concentrated and diluted at normal temperature, then the operation is convenient, but plasmalogen content is significantly reduced

Engineering Contradiction:

Improveoperation convenienceVSAvoidplasmalogen amount

Core Design Contradiction:

Ease of operationVSQuantity of substance

Solution Approach 1:

The patent applies temperature parameter change by conducting concentration and dilution operations under refrigeration (2 to 15°C) instead of at normal temperature. This maintains higher plasmalogen content while the refrigeration equipment provides sufficient operational convenience for industrial production.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method prevents significant reduction of plasmalogen content, enabling the production of a composition containing plasmalogen derived from animal tissue without loss, thereby maintaining higher plasmalogen levels.

Implementation Method 1

concentrating an alcohol extract of a plasmalogen-containing animal tissue

Methodology Applied

Scientific EffectEvaporation: Evaporation

Implementation Method 2

concentrating an alcohol extract of a plasmalogen-containing animal tissue

Methodology Applied

Scientific EffectDistillation: Distillation

Implementation Method 3

after diluting a concentrated product obtained by (A)

Methodology Applied

Scientific EffectDilution:

Implementation Method 4

allowing to stand under refrigeration

Methodology Applied

Scientific EffectCooling: Cooling

Data Source

PatentUS11517594B2Methods for producing compositions containing plasmalogen

Publication Date: 2022.12.06 NIHON PHARMACEUTICAL CO LTD

AI summary

Provided is a method for producing a composition containing plasmalogen derived from a plasmalogen-containing animal tissue, the method being without significantly decreasing an amount of plasmalogen derived the plasmalogen-containing animal tissue. A method for producing a composition containing plasmalogen derived from an animal tissue, the method comprising: (A) concentrating an alcohol extract of a plasmalogen-containing animal tissue, and (B) after diluting a concentrated product obtained by (A), allowing to stand under refrigeration.