Plasmapheresis Plasma Exchange for Age-Associated Factor Removal

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Solution Overview

Problem

Aging-related disorders such as Alzheimer's disease, infections, Type II Diabetes, atherosclerotic cardiovascular disease, obesity, osteoporosis, and sarcopenia impose a significant financial burden on medical systems, and existing treatments do not effectively address the underlying biological changes associated with aging.

Innovation Solution

Plasmapheresis is administered to individuals to measure and improve health status by exchanging plasma volume, modulating cell surface markers, reducing cellular senescence, and removing age-associated factors, with monitoring and adjustments to achieve specific health improvements.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing treatments are used for aging-related disorders, then the financial burden on medical systems is significant, but the treatments do not effectively address the underlying biological changes associated with aging

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidfinancial burden

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent applies plasmapheresis to extract and remove age-associated harmful factors, inflammatory mediators, and cellular debris from the plasma. This extraction approach directly addresses the underlying biological changes of aging by removing pathological substances rather than merely treating symptoms, thereby improving treatment effectiveness while providing a cost alternative to conventional therapies

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The treatment modifies plasma composition parameters by selectively removing harmful substances and replacing plasma volume. This changes the biochemical parameters of the blood, reducing inflammatory markers and age-associated factors, which leads to improved health outcomes and addresses the root causes of aging-related disorders

Inventive Principle:

Principle #35Parameter changes

2Strength

If plasmapheresis is administered to improve health status, then strength, balance, and walking ability are improved, but the treatment requires multiple sessions and monitoring

Engineering Contradiction:

Improvephysical strength and balanceVSAvoidtreatment duration

Core Design Contradiction:

StrengthVSLoss of time

Solution Approach 1:

The patent employs a series of plasmapheresis treatment sessions administered at intervals to continuously remove age-associated harmful factors from the plasma. This continuous therapeutic action maintains improved plasma composition over time, progressively enhancing strength, balance, and walking ability while managing the time investment through structured treatment protocols

Inventive Principle:

Principle #20Continuity of useful action

Solution Approach 2:

The treatment protocol includes monitoring health status parameters before and after treatment sessions to assess improvement in strength, balance, and walking ability. This feedback mechanism allows for optimization of treatment frequency and duration, ensuring therapeutic effectiveness while minimizing unnecessary treatment time

Inventive Principle:

Principle #23Feedback

Data Source

PatentUS20260043804A1Compositions and methods for plasmapheresis

Publication Date: 2026.02.12 CIRCULATE HEALTH INC

AI summary

Described herein are compositions and methods for performing plasmapheresis. The compositions and methods for performing plasmapheresis are innovative at least in their application towards the treatment and prevention of aging and conditions associated with aging. Plasmapheresis compositions and methods described herein are directed towards reducing or eliminating conditions associated with aging.