Ultrastable Plasmonic Bioinks for Biosensor Fabrication
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Solution Overview
Problem
Current sensors, particularly point-of-care biosensors, face limitations such as limited stability, expensive and time-consuming fabrication techniques, and vulnerability to harsh conditions, which restrict their effectiveness in resource-limited settings and sensitivity.
Innovation Solution
Development of ultrastable plasmonic bioinks by encapsulating antibodies with an organosiloxane polymer through in situ polymerization, creating a robust and versatile approach for fabricating sensors that are resistant to thermal, chemical, and mechanical stress, enabling cost-effective and scalable production of multiplex biosensors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If conventional fabrication techniques are used for biosensors, then the sensors can be manufactured, but the fabrication process is expensive and time-consuming
Solution Approach 1:
The patent changes the fabrication parameters by using microfluidic chip technology with standardized protocols, transitioning from conventional complex fabrication to a more parameter-optimized process that reduces both time and cost while maintaining sensor stability through controlled reaction conditions
Solution Approach 2:
The patent employs thin film coatings and microfluidic channel structures that provide flexible, scalable manufacturing platforms, enabling rapid production of stable biosensors through standardized chip designs rather than custom fabrication for each sensor
2Measurement precision
If biosensors are designed for sensitivity, then detection capability is improved, but vulnerability to harsh conditions increases
Solution Approach 1:
The patent applies protective coatings and optimized immobilization strategies beforehand to shield the sensitive biorecognition elements from harsh conditions, providing a cushioning layer that preserves sensor stability without compromising detection sensitivity
Solution Approach 2:
The patent uses composite structures combining biorecognition elements with protective matrices and stabilizing agents, creating a composite material system that simultaneously provides sensitivity for detection and resistance to thermal, chemical, and mechanical stress
3Adaptability or versatility
If point-of-care biosensors are deployed in resource-limited settings, then accessibility is improved, but limited stability restricts effectiveness
Solution Approach 1:
The patent develops disposable microfluidic biosensor chips that are inexpensive to manufacture and use, allowing deployment in resource-limited settings where stability concerns are mitigated by single-use design rather than requiring long-term durability
Solution Approach 2:
The patent optimizes sensor parameters for enhanced stability under varying environmental conditions through standardized fabrication protocols and protective designs, enabling reliable performance across different temperatures and storage conditions in resource-limited settings
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting sensors demonstrate enhanced stability and sensitivity, maintaining biofunctionality under harsh conditions, with improved thermal, biological, and colloidal stability, suitable for resource-limited settings and enabling rapid, accurate diagnostics.
Implementation Method 1
encapsulating antibodies with an organosiloxane polymer through in situ polymerization
Implementation Method 2
ultrastable plasmonic bioinks
Data Source
AI summary
Embodiments of the present disclosure pertain to a sensor that includes a transduction agent, a plurality of analyte binding agents immobilized on the transduction agent, and a coating agent that forms a coating around at least some of the analyte binding agents. Further embodiments of the present disclosure pertain to methods of detecting one or more analytes in a sample by associating the sample with a sensor of the present disclosure; detecting a signal from the sensor; and correlating the signal to the presence or absence of the one or more analytes in the sample. Additional embodiments of the present disclosure pertain to methods of making the sensors of the present disclosure by immobilizing a plurality of analyte binding agents on a transduction agent; and coating at least some of the analyte binding agents with a coating agent to form a sensor.