Plasmonic Chip Silver Nanocrystals Cancer Diagnosis
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Solution Overview
Problem
Current methods for detecting cancer-related substances using plasmonic chips face challenges in mass production and adsorption of cancer-related substances or fluorescence-labeled markers, leading to difficulties in achieving fluorescence enhancement and efficient diagnostic processes.
Innovation Solution
The development of plasmonic chips with silver complex quantum crystals and silver peroxide meso crystals, which enable localized surface plasmon resonance for enhanced fluorescence imaging and selective absorption of cancer-related substances, allowing for easy mass production and improved diagnostic capabilities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If conventional plasmonic chips are used for cancer diagnosis, then the device can be manufactured, but mass production is difficult and adsorption of cancer-related substances is ineffective
Solution Approach 1:
The patent changes the surface properties of the plasmonic chip by controlling the deposition of metal nanoparticles to create specific surface roughness and charge characteristics. This enables effective adsorption of cancer-related substances while maintaining manufacturability through standardized deposition processes.
Solution Approach 2:
The patent creates a composite structure combining metal nanoparticles with the chip substrate, forming a plasmonic chip with enhanced surface properties. This composite material approach improves both manufacturability and adsorption effectiveness by leveraging the properties of each component.
2Measurement precision
If conventional plasmonic chips are used, then fluorescence enhancement can be achieved, but the process is complex and time-consuming
Solution Approach 1:
The patent performs preliminary actions by pre-treating the chip surface with metal nanoparticles and optimizing the plasmonic structure before use. This preparation enables rapid and effective fluorescence enhancement during actual diagnostic procedures, reducing overall process time.
Solution Approach 2:
The patent replaces complex mechanical and chemical processing steps with optimized optical plasmonic effects. By leveraging localized surface plasmon resonance, the system achieves fluorescence enhancement through electromagnetic field interactions rather than complex mechanical manipulation, reducing process time.
3Measurement precision
If existing detection methods are used, then cancer-related substances can be detected, but sensitivity and rapidity are insufficient
Solution Approach 1:
The patent optimizes detection parameters by controlling the size, shape, and distribution of metal nanoparticles on the chip surface. This creates enhanced plasmonic effects that simultaneously improve detection sensitivity and reduce analysis time through faster signal generation.
Solution Approach 2:
The patent introduces metal nanoparticles as intermediary elements that mediate between the cancer-related substances and the detection system. These nanoparticles enhance the interaction between target molecules and detection reagents, improving both sensitivity and rapidity through amplified signal generation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The plasmonic chips facilitate enhanced fluorescence intensity and precise detection of cancer-related substances, enabling early-stage cancer diagnosis through fluorescence imaging and Raman spectroscopy, with improved sensitivity and rapidity compared to existing methods.
Implementation Method 1
enhanced by localized surface plasmon resonance (SPR)
Implementation Method 2
absorb or capture them and analyze their crystallization or aggregation state
Implementation Method 3
observation of auto fluorescence and Raman spectroscopy
Implementation Method 4
analyze their crystallization or aggregation state by fluorescence image diagnosis and SERS analyzation
Data Source
Figure 1A~1B
Figure 1C~2A
Figure 2B~2C
AI summary
[Problem] To provide: a plasmonic substrate; a method for observing fluorescent image of a candor related substance and a method for Raman spectroscopic analysis using the plasmonic substrate. [Solution] In the present invention, a cancer-related substance in blood or a biological sample can be detected in a selective manner, so it becomes possible to determine the occurrence of cancer by observation of fluorescent image of a crystal of the censor related substance or a coagulated state of the crystal on a plasmonic chip. In addition, the state of chemical modification of a histone tail can be determined by a Raman spectrum analysis, so that it becomes possible to detect occurrence of cancer at an earlier stage and to determine stages of progress of cancer. Furthermore, the location of the cancer-related substance aggregated on a substrate cannot be determined with naked eyes. Then, as a second aspect of the present invention, a method for diagnosing a cancer disease is provided, said method being characterized by firstly identifying the location of the region of a crystal by observing fluorescent image on a microscope, and then irradiating the crystal, with laser beam to analyze with respect to the chemical modification of a histone tail and a remodeling factor.