Platelet Aggregation Testing With Integrated Plasma Specimen Adequacy

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Solution Overview

Problem

Existing platelet aggregation function tests face inaccuracies when the platelet count in platelet-rich plasma samples is low, necessitating separate measurements to confirm suitability, which is time-consuming and laborious.

Innovation Solution

A sample measurement apparatus and method that includes a detector to measure optical information of platelet-rich and platelet-poor plasma, a controller to acquire platelet aggregation function information, and a display to evaluate specimen adequacy, allowing direct determination of platelet-rich plasma adequacy within the apparatus.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If platelet count is measured using a separate blood cell counter to confirm sample adequacy, then measurement accuracy is improved, but measurement time and operational complexity increase

Engineering Contradiction:

Improveplatelet aggregation function measurement accuracyVSAvoidtime required for separate platelet count measurement

Core Design Contradiction:

Measurement precisionVSLoss of time

Solution Approach 1:

The patent combines the platelet count measurement function and the platelet aggregation function measurement function into a single blood coagulation test apparatus. The detector measures optical information from platelet-rich plasma, and the controller calculates both platelet count and platelet aggregation function from the same measurement data, eliminating the need for separate measurements with a blood cell counter.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The blood coagulation test apparatus is designed to perform multiple functions: it can measure both platelet count and platelet aggregation function using the same detector and measurement system. This multi-functionality allows the apparatus to determine specimen adequacy and perform aggregation function measurement without requiring additional equipment or separate measurement processes.

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Reliability

If separate blood cell counter measurement is performed to determine specimen adequacy, then reliability of platelet aggregation function measurement is improved, but device complexity increases

Engineering Contradiction:

Improvereliability of platelet aggregation function measurementVSAvoidnumber of measurement devices required

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges the platelet count measurement capability into the blood coagulation test apparatus. The detector measures optical information from platelet-rich plasma, and the controller calculates platelet count from this data, allowing the same device to perform both adequacy assessment and aggregation function measurement.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The blood coagulation test apparatus is designed as a universal device that can perform both platelet count determination and platelet aggregation function measurement. This eliminates the need for multiple specialized devices and simplifies the overall measurement system while maintaining reliability.

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Measurement precision

If separate measurement process is used to evaluate platelet-rich plasma adequacy, then measurement accuracy is improved, but ease of operation deteriorates

Engineering Contradiction:

Improvespecimen adequacy evaluation accuracyVSAvoidoperational simplicity

Core Design Contradiction:

Measurement precisionVSEase of operation

Solution Approach 1:

The patent combines specimen adequacy evaluation and platelet aggregation function measurement into a single integrated process. The detector obtains optical information from platelet-rich plasma, and the controller performs both adequacy assessment and aggregation function calculation from the same data, eliminating the need for separate measurement steps.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The blood coagulation test apparatus automatically determines specimen adequacy and performs platelet aggregation function measurement without requiring separate manual interventions. The system self-evaluates the platelet-rich plasma quality and proceeds with the aggregation function measurement in an integrated automated workflow.

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables easy and accurate determination of platelet-rich plasma specimen adequacy, improving the usability and reliability of platelet aggregation function measurements.

Implementation Method 1

a detector configured to measure optical information of platelet-rich plasma and platelet-poor plasma prepared from the blood sample

Methodology Applied

Scientific EffectOptical measurement: Absorption Spectroscopy

Data Source

PatentUS20250258186A1Sample measurement apparatus and sample measurement method

Publication Date: 2025.08.14 SYSMEX CORP

AI summary

A sample measurement apparatus according to an embodiment may be a sample measurement apparatus for measuring a platelet aggregation function of a blood sample. The apparatus may include: a detector configured to measure optical information of platelet-rich plasma and platelet-poor plasma prepared from the blood sample; a controller configured, based on the optical information of the platelet-rich plasma and the platelet-poor plasma, to acquire information regarding the platelet aggregation function of the blood sample; and a display configured to display the information regarding the platelet aggregation function. The controller is configured to obtain, based on measurement result of the platelet-rich plasma by the detector, evaluation information regarding adequacy of the platelet-rich plasma as a specimen, and display the evaluation information on the display.