Standardizing Platelet Function Measurement Across PFA Cell Types

The patent applies parameter changes by introducing a normalization parameter (reference value) that transforms the raw closure time measurements into standardized platelet function values. Different measuring cell types produce different closure times, but by dividing each closure time by its corresponding reference value, the results are normalized to a common scale, enabling comparison across different cell types while maintaining the ability to examine various platelet activation pathways.

The patent replaces the direct mechanical measurement of closure time with a calculated derived value (platelet function value). Instead of comparing raw closure times directly, the system substitutes them with normalized values calculated by dividing closure time by reference values. This substitution transforms the measurement into a standardized metric that maintains reliability for platelet function assessment while eliminating the comparability issues of raw closure times across different cell types.

The patent achieves universality by creating a standardized reference framework that applies across all measuring cell types. Each cell type has its own reference value determined from healthy donor samples, but these reference values are used to normalize results from all cell types to a common scale. This allows the system to maintain the ability to target specific activation pathways with different cell types while achieving overall standardization through the unified normalization approach.