Platelet Gel Bio-membrane for Tissue Regeneration
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Solution Overview
Problem
Current methods for tissue regeneration and repair, such as using ceramic scaffolds with patient's own cells, face challenges like lack of vascularization leading to cell death and limited applicability, especially for skin lesions and soft tissue repairs.
Innovation Solution
A bio-membrane composed of platelet gel with thrombin and calcium gluconate, covered by a hyaluronic acid patch, which can induce neo-tissue formation when implanted, accelerating healing and vascularization in both bone and soft tissue repairs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If ceramic scaffolds with patient's own cells are used for tissue regeneration, then bone reconstruction capability is improved, but lack of vascularization leads to cell death and reduces reliability
Solution Approach 1:
The patent applies preliminary action by pre-forming a vascularized tissue membrane from patient's own cells before implantation. This membrane is cultured in advance to develop vascular networks, so that when implanted with the ceramic scaffold, the vascularization is already established, preventing cell death from lack of blood supply.
Solution Approach 2:
The patent uses a tissue-cultured membrane as an intermediary between the ceramic scaffold and the host's vascular system. This membrane acts as a mediator that bridges the gap, providing pre-formed vascular channels that connect to the host's circulation, thereby solving the vascularization problem.
2Adaptability or versatility
If periosteum residues are used to trigger bone formation, then vascularization and bone repair are improved, but applicability is limited due to rarity of periosteum availability
Solution Approach 1:
The patent creates a universal solution by using adipose tissue-derived stem cells or bone marrow stem cells that can be obtained from virtually any patient through liposuction or bone marrow aspiration. These cells are cultured to form a vascularized membrane that can be applied to various bone defects, making the technique universally applicable rather than limited to specific periosteum cases.
3Productivity
If platelet gel is applied locally to repair skin lesions, then healing acceleration is improved, but structural support and tissue regeneration are insufficient
Solution Approach 1:
The patent merges platelet gel's rapid healing properties with the structural support of ceramic scaffolds and the vascularization capability of cultured tissue membranes. The platelet gel is incorporated into the membrane structure during culture, combining the benefits of fast healing acceleration with robust structural regeneration and vascular supply.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bio-membrane effectively promotes cell proliferation and bone tissue formation, and accelerates skin lesion repair by providing essential biological factors, maintaining cell vitality even when partially dehydrated, and is applicable for various tissue deficits and lesions.
Implementation Method 1
a bio-membrane constituted by a platelet gel comprising a platelet concentrate, thrombin and calcium gluconate
Implementation Method 2
said biomenbrane being covered by a patch of hyaluronic acid for use in the treatment of skin lesions
Data Source
AI summary
A bio-membrane with angiogenic activity for implant in 'tissue regeneration and repair, including bone reconstruction and the repair of skin and soft tissue lesions is described, essentially constituted by a gel able to provide support and growth and/or differentiation and/or angiogenic factors for the full in vivo functionality of the cell, containing also mesenchymal stem/precursor cells, an implant device for reconstructive surgery of bone tissue, of skin and soft tissue lesions which comprises the bio-membrane, and a method for its obtainment. Use of the gel alone for tissue regeneration and of adhesive plasters that comprise it is also described.