Centrifugal Infusion of Activated Platelets into Solid Bone Grafts
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Solution Overview
Problem
Current methods for enhancing therapeutic properties of solid graft materials in orthopedic surgeries are limited by risks such as poor healing of the bone receiving the graft and potential infections from donated bone.
Innovation Solution
A method involving the infusion of fluid biologics, such as human platelets, stem cells, or platelet-rich plasma, into solid graft materials using a centrifugation process to enhance their therapeutic properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If donated bone is used for grafting, then bone grafting can be performed, but risk of infection increases
Solution Approach 1:
The patent introduces an intermediary processing system (centrifugal infusion device) that acts as a mediator between the donor bone and the recipient patient. The device infuses allogeneic platelets and plasma through the bone graft material, creating a biological barrier that reduces infection risk while maintaining the graft's structural integrity and healing properties.
Solution Approach 2:
The patent changes the biological parameters of the bone graft material by infusing it with activated platelets and plasma. This transformation converts the static graft material into a dynamically enhanced product with improved healing properties, reduced infection risk, and enhanced osteoinductivity without changing the fundamental nature of the donated bone.
2Ease of manufacture
If traditional bone grafting is performed, then bone structure can be rebuilt, but healing quality may be poor
Solution Approach 1:
The patent applies preliminary action by pre-infusing the bone graft material with allogeneic platelets and plasma before implantation. This advance preparation ensures that the graft material is already optimized for healing when it reaches the patient, eliminating the need for complex intraoperative processing while guaranteeing enhanced healing quality.
Solution Approach 2:
The patent creates a composite material system by combining donated bone with allogeneic platelets and plasma. This composite approach merges the structural advantages of donated bone with the healing-enhancing properties of platelet-rich plasma, resulting in a superior graft material that maintains simplicity of use while dramatically improving healing outcomes.
3Reliability
If multiple surgeries are performed to extract and transplant bone, then patient-specific bone graft can be obtained, but surgical complexity and time increase
Solution Approach 1:
The patent introduces an intermediary solution (allogeneic platelet infusion) that bridges the gap between the need for patient-specific compatibility and the desire to avoid multiple surgeries. By infusing processed platelets from healthy donors into the bone graft, the system achieves biological enhancement without requiring the patient to undergo additional bone extraction procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The enhanced solid graft materials demonstrate improved healing potential and reduced risk of complications, allowing for more effective bone fusion and repair during orthopedic procedures.
Implementation Method 1
placing the centrifuge container into a centrifuge and centrifuging the solid graft material and the activated human platelets to form an enhanced solid graft material
Data Source
AI summary
A method of enhancing therapeutic properties of a solid graft material with a fluid biologic may include obtaining the solid graft material and obtaining the fluid biologic to be fluidically infused with the solid graft material. The fluid biologic may include human platelets, activating the human platelets with an activation fluid to form activated human platelets, placing the solid graft material into a centrifuge container, adding the activated human platelets to the solid graft material in the centrifuge container, and placing the centrifuge container into a centrifuge and centrifuging the solid graft material and the activated human platelets to form an enhanced solid graft material.