Platelet Pooling and Segmentation for Therapeutic Dose Production
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Solution Overview
Problem
Current methods for collecting and preparing apheresis-derived platelet units are inefficient, as they often result in excess platelets being retained without providing additional therapeutic value, and there is a need for improved systems to maximize platelet unit production.
Innovation Solution
A method involving the collection of platelet donations by apheresis from multiple donors, pooling these donations, and separating them into a greater number of platelet units than would be possible without combination, allowing for each unit to contain a therapeutic dose of platelets, even if individual donations fall short of the minimum required for a single unit.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If apheresis platelet donations are collected to meet minimum therapeutic dose criteria for one, two or three platelet units, then each unit contains the required minimum number of platelets, but excess platelets are retained without providing additional therapeutic value
Solution Approach 1:
The patent combines multiple apheresis platelet donations (singles, doubles, triples) into a pooled platelet preparation, then redistributes the pooled platelets to create additional therapeutic-dose units. This merging approach allows efficient utilization of excess platelets that would otherwise be discarded, thereby increasing overall platelet unit production while maintaining reliable therapeutic doses.
2Object-affected harmful factors
If platelet collections are limited to meet specified thresholds for one, two or three platelet units, then donor safety is ensured, but the potential production capacity of platelet units is not fully captured
Solution Approach 1:
The patent performs pooling of platelet donations before final unit creation, allowing advance assessment of total platelet availability. This preliminary pooling action enables the system to maximize unit production from available donations while still adhering to donor safety limits, as the pooling occurs after individual donation safety thresholds are already met.
3Manufacturing precision
If individual apheresis donations are processed separately to meet minimum platelet counts, then each unit meets therapeutic criteria, but fewer total units are produced compared to pooled processing
Solution Approach 1:
The patent segments the pooled platelet preparation into multiple individual therapeutic-dose units after pooling. This segmentation approach allows the system to create the maximum number of compliant units from the pooled material, ensuring each segmented unit meets therapeutic criteria while maximizing total unit production beyond what separate processing would achieve.
Data Source
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AI summary
Provided are methods, systems and compositions for the preparation of platelets, including improved methods and systems for preparing apheresis derived platelet units suitable for infusion and compositions comprising such platelet units.