Protective Compounds for Platelet Storage Lesion Prevention
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Solution Overview
Problem
Current methods for storing blood platelets are limited by bacterial proliferation at room temperature and cold-induced platelet storage lesions when cooled, leading to premature expiration and functional damage, necessitating the development of new compounds that can protect cells and platelets against oxidative stress and storage-related injuries.
Innovation Solution
Development of specific compounds, such as those with the structural formula (I), which protect cells and blood platelets by preventing damage from oxidative stress, cold storage lesions, and other medical indications, including ischemia and thrombotic disorders, by inhibiting cell death and maintaining platelet functionality during storage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If blood platelets are stored at room temperature (20-24°C), then platelet functionality is maintained, but bacterial proliferation occurs leading to premature expiration
Solution Approach 1:
The patent changes the storage temperature parameter from room temperature to refrigerated temperature (4°C), and introduces compounds that modify platelet membrane properties to prevent cold-induced damage. This parameter change allows bacterial suppression while maintaining platelet viability through chemical protection.
Solution Approach 2:
The patent introduces compounds as intermediary substances that mediate between the cold storage environment and platelets. These compounds act as protective agents that prevent direct harmful effects of cold temperature on platelet membranes, enabling safe refrigerated storage.
2Object-affected harmful factors
If blood platelets are cooled to 4°C, then bacterial proliferation is prevented, but cold-induced platelet storage lesions occur causing structural and functional damage
Solution Approach 1:
The patent applies compounds to platelets before cold storage to provide protective cushioning. These compounds are incorporated into platelet membranes in advance, creating a protective layer that cushions against cold-induced structural damage during subsequent refrigerated storage.
Solution Approach 2:
The patent creates a composite system combining platelets with protective compounds. The compounds integrate with platelet membrane structures to form a composite material that maintains platelet integrity under cold storage conditions, preventing structural lesions while enabling bacterial suppression.
3Productivity
If storage time is extended beyond 5 days, then more platelets can be utilized, but platelet viability decreases due to storage lesions
Solution Approach 1:
The patent performs preliminary action by incorporating protective compounds into platelet membranes before storage. This preliminary protection enables extended storage periods while maintaining viability, allowing platelets to be stored longer than the conventional 5-day limit without significant loss of functionality.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compounds effectively reduce cell death and maintain platelet functionality during storage, extending the viability and usability of blood platelets, and can be used in treating conditions related to oxidative stress and thrombotic disorders.
Implementation Method 1
oxidative stress in cells and cell damage are often related with aging and diseases related to aging
Implementation Method 2
compounds such as nitrones can be used in the treatment of ischemic stroke and as anti-cancer agents
Implementation Method 3
Platelets show cold induced platelet storage lesion (PSL) when they are cooled, even briefly to 4°C
Implementation Method 4
reversible to irreversible morphological change from a discoid cell to speculated spheres with protruding filipodia, depending on the duration of exposure to temperatures less than 20°C
Data Source
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AI summary
This invention is related to a compound for certain uses with the structural formula (I) wherein, R1, and R2 are independently selected from the group consisting of C1-C6 alkyl and is preferably methyl, ethyl, propyl or isopropyl; R3 is selected from the group consisting of CH2NHR9, C(=O)YR10, -CH2OH