PLGA PDO Microparticle Filler via Plasma Treatment
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Solution Overview
Problem
Current biodegradable polymer microparticles, such as PLLA, PCL, and PLGA, used in fillers face challenges with short decomposition periods and high hydrophobicity, leading to inadequate collagen regeneration due to poor cell adhesion, while PDO microparticles have a short persistence in the body, necessitating a composition that enhances cell adhesion and maintains collagen for a longer duration.
Innovation Solution
A method involving a mixture of PLGA and PDO microparticles, with PLGA constituting 50-90% of the mixture, undergoes plasma surface treatment and is combined with a dispersant, then freeze-dried to create a filler composition that promotes cell adhesion and prolonged collagen maintenance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If hydrophobic biodegradable polymer microparticles (PLLA, PCL, PLGA) are used to maintain filler persistence for over a year, then the decomposition period is extended, but cell adhesion becomes difficult and collagen regeneration is slow or inadequate
Solution Approach 1:
The patent combines PDO microparticles (hydrophilic, short decomposition period) with PLGA microparticles (hydrophobic, long decomposition period) in a mixed composition. This merging allows the PDO component to provide good cell adhesion and collagen regeneration in the early stage, while the PLGA component ensures long-term filler persistence and structural support, thus resolving the contradiction between decomposition period and cell adhesion capability
Solution Approach 2:
The patent applies plasma surface treatment specifically to the microparticle surface to modify its properties. This local treatment introduces polar groups and increases surface hydrophilicity without changing the bulk hydrophobic properties of the polymer. The result is improved cell adhesion on the surface while maintaining the long decomposition period of the hydrophobic core material
2Reliability
If PDO microparticles are used to enhance cell adhesion and collagen regeneration, then cell adhesion is improved, but the decomposition period becomes too short for long-term maintenance
Solution Approach 1:
The patent creates a composite filler system merging PDO microparticles (providing excellent cell adhesion and collagen regeneration) with PLGA microparticles (providing long-term structural support and persistence). The PDO component handles the early-stage biological integration, while the PLGA component maintains the filler structure for over a year, thus resolving the contradiction between cell adhesion and decomposition period
Solution Approach 2:
The PLGA microparticles act as an intermediary that extends the functional lifespan of the filler system. While PDO provides the biological interface for cell adhesion, the PLGA component ensures the filler structure persists long-term, mediating between the short-lived PDO and the long-term structural requirements
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The filler composition effectively enhances cell adhesion and collagen generation, reducing side effects and maintaining tissue restoration for an extended period by balancing the decomposition rates of PLGA and PDO microparticles.
Implementation Method 1
injecting plasma into the mixture to perform a plasma surface treatment on the PLGA microparticles and the PDO microparticles
Implementation Method 2
freeze-drying the dispersant solution to form the composite containing the PLGA microparticles and the PDO microparticles
Implementation Method 3
microparticles formed of hydrophobic biodegradable polymers are excreted in urine by being completely decomposed by hydrolysis in the body
Data Source
AI summary
The present disclosure relates to a method for preparing a filler composition for molding. The method for preparing a filler composition for molding includes the operations of: a) providing PLGA microparticles consisting of poly (lactic-co-glycolic acid) (PLGA), a biodegradable polymer; b) providing PDO microparticles consisting of polydioxanone (PDO); c) preparing a mixture by mixing the PLGA microparticles and the PDO microparticles; d) injecting plasma into the mixture to perform a plasma surface treatment on the PLGA microparticles and the PDO microparticles; e) dispersing the plasma-treated mixture into a solution containing a dispersant composition to prepare a dispersant solution; and f) freeze-drying the dispersant solution to form the composite containing the PLGA microparticles and the PDO microparticles.