Pliable Member with Micrometer Projections for Non-Invasive Fluid Analysis

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Solution Overview

Problem

Conventional methods for examining an organism's health status are invasive, painful, and limited in sensitivity, especially for detecting soft tissue infections or inflammation, and are ineffective for organisms with intact skin or non-volatile organic substances.

Innovation Solution

A pliable member with a contact layer, micrometer-sized spherical projections, and biocompatibility channels and reaction layers that absorb and analyze body fluids, allowing for non-invasive detection of health or illness through visible changes or fluorescence.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If blood is taken for examination, then health status can be examined, but the organism feels pain and discomfort

Engineering Contradiction:
Improveexamination capabilityVSAvoidpain and discomfort
Core Design Contradiction:
Measurement precisionVSObject-affected harmful factors

Solution Approach 1:

The invention extracts the examination function from invasive blood drawing and relocates it to non-invasive interstitial fluid collection through the pliable member contact layer, eliminating pain while preserving diagnostic capability

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The pliable member acts as an intermediary device between the organism and the examination system, collecting interstitial fluid through the contact layer without direct blood extraction, thereby mediating between non-invasive collection and diagnostic analysis

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If conventional exudate fluid collection is used, then metabolic substances can be examined, but the method is useless for organisms with intact skin

Engineering Contradiction:
Improvesubstance detection capabilityVSAvoidapplicability to intact skin
Core Design Contradiction:
Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The contact layer is designed with micrometer-sized spherical projections that create porous structures capable of passively absorbing interstitial fluid through intact skin, enabling fluid collection without breaking the skin barrier

Inventive Principle:
Principle #31Porous materials

Solution Approach 2:

The pliable member features localized micrometer-scale spherical projections on the contact layer that create specific absorption zones, enabling targeted interstitial fluid collection from intact skin while maintaining overall device flexibility and comfort

Inventive Principle:
Principle #3Local quality

3Measurement precision

If repeated blood drawing is performed, then longitudinal monitoring can be achieved, but the procedure becomes tedious and time consuming

Engineering Contradiction:
Improvelongitudinal monitoring capabilityVSAvoidprocedure time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The pliable member with pre-configured contact layer and micrometer projections is prepared in advance for prolonged wear, enabling continuous passive interstitial fluid collection over time, thereby eliminating repeated procedural interventions and reducing total examination time

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables painless, sensitive, and non-invasive examination of both volatile and non-volatile substances, effectively determining health or illness based on fluid analysis without causing discomfort, even for organisms with intact skin.

Implementation Method 1

the spherical projections for examination are able to collect fluid of the organism as a collected fluid

Methodology Applied
Scientific EffectCapillary action: Capillary Action

Implementation Method 2

examining a target substance of the collected fluid from the organism and changing color of a reaction layer or emitting fluorescence

Methodology Applied
Scientific EffectFluorescence: Fluorescence

Data Source

PatentUS11903735B2Apparatus of examining surface of an organism and method thereof
Publication Date: 2024.02.20 CHANG GUNG UNIVERSITY
  • US11903735B2 patent drawing
  • US11903735B2 patent drawing
  • US11903735B2 patent drawing

AI summary

An apparatus and method for examining an organism surface includes a pliable member including a contact layer, a plurality of channels, and a reaction layer, wherein the plurality of channels are disposed between the contact layer and the reaction layer; each of the channels having a size in the range of micrometers and formed of biocompatibility materials, and the contact layer including a plurality of spherical projections having a size in the range of micrometers and formed of biocompatible materials, and the reaction layer including examining molecules and a reaction unit.