Pluribioactive Antifungal Drug Controlled Release Systems
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Solution Overview
Problem
Current antifungal drugs are primarily used for treating fungal infections and lack exploration for additional bioactivities such as antineoplastic, antibacterial, antirestenotic, and spermiostatic effects, despite their potential pluribioactive properties.
Innovation Solution
Development of controlled release systems for pluribioactive antifungal drugs like miconazole and ketoconazole, incorporating them into absorbable or non-absorbable polymeric systems for applications beyond fungal infections, including cancer treatment, vascular restenosis prevention, and contraception.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If antifungal drugs are used solely for treating fungal infections, then their antifungal efficacy is optimized, but their potential additional bioactivities (antineoplastic, antibacterial, antirestenotic, spermiostatic) remain unexploited
Solution Approach 1:
The patent applies multi-functionality by formulating antifungal drugs (miconazole, ketoconazole, itraconazole, voriconazole, amphotericin B) in controlled release systems that enable them to perform multiple bioactivities simultaneously - antifungal, antineoplastic, antibacterial, antirestenotic, and spermiostatic effects - thereby resolving the contradiction between versatility and system complexity
Solution Approach 2:
The patent utilizes parameter changes by modifying the release characteristics and concentration profiles of antifungal drugs through controlled release formulations, allowing the same drug to exhibit different bioactivities at different concentrations and time points, thus enabling pluribioactive potential without requiring multiple separate drugs
2Duration of action of moving object
If azole-type antifungal drugs are used in controlled delivery systems, then their bioavailability and sustained release are improved, but their water insolubility creates formulation challenges
Solution Approach 1:
The patent employs intermediaries in the form of controlled release matrices and carriers that facilitate the incorporation and sustained release of water-insoluble azole-type antifungal drugs, enabling prolonged duration of action while overcoming formulation challenges through appropriate matrix selection and drug formulation techniques
3Adaptability or versatility
If multiple bioactivities are pursued with a single drug, then therapeutic versatility is enhanced, but the complexity of developing and regulating multiple indications increases
Solution Approach 1:
The patent applies preliminary action by conducting in vitro and in vivo studies to preliminarily establish the pluribioactive potential of antifungal drugs before clinical application, demonstrating antifungal, antineoplastic, antibacterial, antirestenotic, and spermiostatic activities through controlled release systems, which builds the foundation for reliable multi-indication use
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The controlled release systems effectively manifest additional bioactivities, demonstrating significant inhibition of cancer cells, bacterial and fungal growth, and sustained drug release profiles, showcasing the pluribioactive potential of miconazole and ketoconazole.
Implementation Method 1
controlled release systems for pluribioactive antifungal drugs
Implementation Method 2
absorbable or non-absorbable polymeric systems
Data Source
AI summary
Controlled release systems release at least one pluribioactive antifungal drug exhibiting at least one additional bioactivity from the group consisting of spermiostatic, antineoplastic, antibacterial, antirestenotic and antiviral activities. The drug release system is designed for use as a spermiostatic contraceptive, intravaginal ringed-mesh which may also exhibit antiviral activity, an in situ-forming implant for treating different forms of cancer and topical film for treating or preventing bacterial and fungal infections.