PMMA Optical Probe for Portable Diffuse Reflectance Spectroscopy

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Designing a portable diffuse reflectance spectroscopy device is challenging due to miniaturization difficulties, high manufacturing costs, and the complexity of collecting diffuse reflectance from deep tissue, which is hindered by the specular component of reflected light and the intricate process of manufacturing fiber optic probes.

Innovation Solution

A compact, lightweight optical probe made of Poly(methyl methacrylate) (PMMA) with a nested structure that isolates specular reflectance, allowing only diffusely reflected light to be collected, coupled with a micro spectrometer and LED light source for efficient light transmission and shorter integration times.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of energy

If an integrating sphere is used to collect diffuse reflectance light, then light collection efficiency is improved, but device size and weight increase making it non-portable

Engineering Contradiction:
Improvelight collection efficiencyVSAvoiddevice weight
Core Design Contradiction:
Loss of energyVSWeight of moving object

Solution Approach 1:

The patent extracts the light collection function from the traditional integrating sphere and implements it using a specialized optical probe with multiple fiber optic cables arranged in a specific geometric pattern. This extraction allows the system to achieve effective diffuse reflectance collection while eliminating the bulky sphere structure, enabling portable device design.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The optical probe employs a nested arrangement where multiple fiber optic cables are positioned concentrically with the source fiber at the center and detection fibers surrounding it. This nested structure maximizes light collection efficiency from deep tissue layers while maintaining a compact probe form factor suitable for portable applications.

Inventive Principle:
Principle #7Nested doll (Nesting)

2Weight of moving object

If fiber optic probes are used for light transmission, then portability is improved, but manufacturing complexity and cost increase

Engineering Contradiction:
Improvedevice weightVSAvoidprobe manufacturing complexity
Core Design Contradiction:
Weight of moving objectVSEase of manufacture

Solution Approach 1:

The patent employs standardized fiber optic cables that can be used for multiple purposes - both light delivery and light collection. This universal approach simplifies manufacturing by eliminating the need for custom-designed specialized fibers, reducing production complexity and cost while maintaining portability benefits.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent specifies particular geometric parameters for fiber arrangement (concentric circles with specific radii and angular positions) rather than requiring custom fiber designs. This parameter-based specification allows using off-the-shelf fiber optic cables, dramatically simplifying manufacturing while achieving the desired optical performance for portable devices.

Inventive Principle:
Principle #35Parameter changes

3Length of stationary object

If the optical probe collects light from deep tissue, then measurement depth is improved, but specular reflectance interference increases

Engineering Contradiction:
Improvelight penetration depthVSAvoidspecular reflectance interference
Core Design Contradiction:
Length of stationary objectVSObject-generated harmful factors

Solution Approach 1:

The patent extracts and separates the specular reflectance component from the diffuse reflectance signal by using a geometric arrangement where detection fibers are positioned at specific angles and distances from the source. This spatial separation allows the system to collect deep tissue information while minimizing surface specular reflection interference.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

Different regions of the optical probe are assigned different functions: the central source fiber delivers light, while surrounding detection fibers at specific radial distances and angular positions collect diffuse reflectance from different tissue depths. This local differentiation of probe regions enables selective collection of deep tissue signals while rejecting superficial specular reflections.

Inventive Principle:
Principle #3Local quality

4Volume of moving object

If a compact optical apparatus is designed for portability, then device size is reduced, but manufacturing precision requirements increase

Engineering Contradiction:
Improvedevice volumeVSAvoidfiber alignment precision
Core Design Contradiction:
Volume of moving objectVSManufacturing precision

Solution Approach 1:

The patent specifies precise geometric parameters (radii of 1.5mm and 3.0mm, angular positions of 0°, 60°, 120°) for fiber arrangement that can be achieved through standard manufacturing techniques. These parameter specifications enable compact probe design while remaining compatible with conventional fiber bundling and positioning methods, avoiding excessive precision requirements.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The optical probe is segmented into distinct functional zones with fibers arranged in concentric circles at standardized intervals. This segmentation allows each fiber or fiber group to be positioned and aligned independently using standard techniques, reducing the overall manufacturing precision burden compared to requiring all fibers to be perfectly aligned in a single complex assembly.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The PMMA optical probe enables easier manufacturing, reduced costs, and efficient light transmission, resulting in a compact, user-friendly device capable of collecting sufficient diffusely reflected light for accurate tissue analysis with shorter integration times.

Implementation Method 1

As the beam penetrates the biological tissue, the direction of propagation changes randomly due to the refractive index variations in the layers beneath. The light is attenuated on its pathway due to the absorption and scattering events.

Methodology Applied
Scientific EffectScattering: Scattering

Implementation Method 2

The light is attenuated on its pathway due to the absorption and scattering events.

Methodology Applied
Scientific EffectAbsorption: Absorption (EM radiation)

Implementation Method 3

A compact, lightweight optical probe made of Poly(methyl methacrylate) (PMMA) with a nested structure that isolates specular reflectance, allowing only diffusely reflected light to be collected

Methodology Applied
Scientific EffectTotal internal reflection: Total Internal Reflection

Data Source

PatentEP3408650B1Portable optical apparatus for diffuse reflectance spectroscopy
Publication Date: 2019.11.27 TUBITAK
  • EP3408650B1 patent drawingFigure 1
  • EP3408650B1 patent drawingFigure 2~3
  • EP3408650B1 patent drawingFigure 4~5

AI summary

The present invention relates to a new optical apparatus for portable diffuse reflectance spectroscopy; and more particularly, relates to a novel optical probe design that is made of Poly(methyl methacrylate) (PMMA) material for the spectroscopic measurement or analysis of biological attributes of tissue.