Pneumatic Needle Separation of Corneal Tissue Layers

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Solution Overview

Problem

Existing corneal transplant procedures, such as penetrating keratoplasty and deep anterior lamellar keratoplasty, face challenges in efficiently and precisely separating corneal tissue layers, particularly the stroma from Descemet's membrane, which can affect the invasiveness and success of the transplant.

Innovation Solution

A separation device with needles that deliver controlled air pressure through a network of channels to separate the stroma from Descemet's membrane, utilizing multiple air supplies and vacuum stabilization for precise tissue separation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If traditional mechanical separation methods are used to separate corneal tissue layers, then the separation can be achieved, but the procedure becomes more invasive and carries higher risk of damage to surrounding tissue

Engineering Contradiction:
Improveinvasiveness and tissue damage riskVSAvoidtissue separation difficulty
Core Design Contradiction:
Object-affected harmful factorsVSEase of operation

Solution Approach 1:

The patent employs pneumatic pressure delivered through needles to separate corneal tissue layers. Air is pumped through needles positioned between the stroma and Descemet's membrane, using pneumatic pressure to create a separation plane without mechanical contact or cutting instruments, thereby reducing invasiveness while achieving effective tissue separation

Inventive Principle:
Principle #29Pneumatics and hydraulics

Solution Approach 2:

The patent introduces air as an intermediary substance to facilitate tissue separation. The air acts as a mediator that pushes the stroma away from Descemet's membrane, enabling separation without direct mechanical interaction between surgical instruments and the delicate corneal layers, thus minimizing tissue damage risk

Inventive Principle:
Principle #24Intermediary (Mediator)

2Manufacturing precision

If multiple needles are used to deliver air pressure for tissue separation, then the separation precision is improved, but the device complexity increases

Engineering Contradiction:
Improvetissue separation precisionVSAvoidseparation device structure
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The separation device is segmented into multiple needles, each capable of delivering air pressure to specific locations within the cornea. This segmentation allows precise control over the separation process at different zones, enabling targeted and controlled tissue separation while maintaining manageable device complexity through modular needle design

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables less invasive corneal transplant procedures by efficiently separating corneal tissue layers, reducing the risk of immune rejection and improving surgical precision.

Implementation Method 1

The one or more air supply channels are configured to direct the air from the one or more air supplies into the proximal openings, through the passageways, and out the distal openings of the needles and into the tissue of the eye. The air applies a pressure to separate the tissue of the eye.

Methodology Applied
Scientific EffectAir pressure: Pressure Increase

Data Source

PatentUS12453574B2Systems and methods for separating tissue in corneal transplant procedures
Publication Date: 2025.10.28 CORNEAGEN INC
  • US12453574B2 patent drawing
  • US12453574B2 patent drawing
  • US12453574B2 patent drawing

AI summary

A device for separating tissue in an eye includes a body configured to be positioned on the eye surface. The body receives air from one or more air supplies. The body includes one or more air supply channels. The separation device includes a plurality of needles extending from the body. Each needle includes a proximal opening, a distal opening, and a passageway extending between the proximal and distal openings. The proximal openings of the needles are coupled to the one or more air supply channels. The distal openings of the needles are spaced from the body to be positioned in eye tissue. The one or more air supply channels direct the air from the one or more air supplies into the proximal openings, through the passageways, and out the distal openings of the needles and into the eye tissue. The air applies a pressure to separate the eye tissue.