Point-of-Care Test Sample Channel Uniform Wetting
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Solution Overview
Problem
Current point-of-care (PoC) test systems face challenges in ensuring uniform and simultaneous sample wetting of test sites, leading to reproducibility and quality issues due to non-uniform application of sample fluid.
Innovation Solution
A test method where a sample fluid is conducted through a sample channel to a discharge area, forming a drop that adheres and expands to contact a wetting point, allowing the fluid to penetrate and react with test reagents on a surface, utilizing a widened area to control drop size and position for optimal contact and reaction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If tube systems are used to supply sample to membrane, then controlled and selective supply of sample is achieved, but uniform application and homogeneity of individual samples from overall sample pool is not ensured
Solution Approach 1:
The sample supply system is divided into multiple separate channels, each leading to an individual test site on the membrane. This segmentation allows each channel to independently deliver a controlled amount of sample to its specific test site, ensuring both controlled supply and uniform distribution across all test sites simultaneously
Solution Approach 2:
Each channel is designed with specific local characteristics (such as channel diameter, length, and geometry) optimized for its function. The channels may have different dimensions or configurations tailored to deliver precise sample volumes to different test sites, ensuring uniform application while maintaining selective control
2Productivity
If rapid test methods without equipment are used, then rapid testing for analytes is achieved, but uniform and simultaneous sample wetting of test sites cannot be ensured
Solution Approach 1:
The sample channels are pre-configured in the device structure before the test is performed. The channels are designed with specific geometries and dimensions that automatically ensure uniform sample distribution when sample is applied, eliminating the need for complex equipment during actual testing while maintaining reliability
Solution Approach 2:
The sample channels act as intermediaries between the sample application point and the test sites on the membrane. These channels mediate the sample flow, distributing it uniformly across all test sites simultaneously without requiring external equipment, thus maintaining both rapid testing and reliable reproducibility
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method ensures uniform and reproducible wetting of test sites, improving the quality and consistency of PoC test results by ensuring equal sample distribution and reaction with test reagents.
Implementation Method 1
as a result of the capillary action of the first surface and/or the pressure applied to the sample channel, penetrates from the second surface toward the first surface
Implementation Method 2
The sample fluid, as a direct result of the stated contact with the wetting point, or as a result of the capillary action of the first surface and/or the pressure applied to the sample channel, penetrates from the second surface toward the first surface
Data Source
AI summary
The present invention relates to a test system or assay system (detection system) and to a test method, preferably in use in the point-of-care (PoC) field.